Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE3B | Q13370 | 2/20 | 0.54 |
| ▸ | PDE3A | Q14432 | 2/20 | 0.54 |
| ▸ | PDE2A | O00408 | 1/20 | 0.54 |
| ▸ | GPR119 | Q8TDV5 | 17/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.43 |
| ▸ | HPGD | P15428 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9687144 | 0.88 | PDE3B (0.54) | PDE3BPDE3APDE2AGPR119KDM4E | |
| SCHEMBL7323542 | 0.85 | PDE3B (0.60) | PDE3BPDE3APDE2AKDM4EALDH1A1 | |
| SCHEMBL9686819 | 0.81 | GPR119 (0.46) | PDE3BPDE3APDE2AGPR119KDM4E | |
| SCHEMBL9686762 | 0.81 | GPR119 (0.66) | PDE3BPDE3APDE2AGPR119 | |
| SCHEMBL9686758 | 0.80 | PDE2A (0.62) | PDE3BPDE3APDE2AGPR119 | |
| SCHEMBL7296954 | 0.78 | GPR119 (0.63) | PDE3BPDE3APDE2AGPR119 | |
| SCHEMBL6052812 | 0.78 | PDE3B (0.71) | PDE3BPDE3APDE2AGPR119KDM4E | |
| SCHEMBL6052809 | 0.78 | PDE3B (0.71) | PDE3BPDE3APDE2AGPR119KDM4E | |
| SCHEMBL7297153 | 0.76 | PDE2A (0.57) | PDE3BPDE3APDE2AGPR119 | |
| SCHEMBL6934629 | 0.75 | PDE2A (0.57) | PDE3BPDE3APDE2AGPR119 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |