Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 2/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | GFER | P55789 | 1/20 | 0.45 |
| ▸ | PDE3B | Q13370 | 15/20 | 0.42 |
| ▸ | PDE3A | Q14432 | 15/20 | 0.42 |
| ▸ | HRH3 | Q9Y5N1 | 2/20 | 0.36 |
| ▸ | TNNC1 | P63316 | 1/20 | 0.36 |
| ▸ | PDE2A | O00408 | 1/20 | 0.35 |
| ▸ | PDE4A | P27815 | 2/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9686825 | 0.88 | GPR119 (0.46) | GPR119MAPTKDM4EALDH1A1CYP2C9 | |
| SCHEMBL7323542 | 0.84 | PDE3B (0.60) | MAPTKDM4EALDH1A1CYP2C9HPGD | |
| SCHEMBL7303555 | 0.81 | PDE3B (0.54) | GPR119MAPTKDM4EALDH1A1CYP2C9 | |
| SCHEMBL9687501 | 0.80 | GPR119 (0.52) | GPR119KDM4EALDH1A1PDE3BPDE3A | |
| SCHEMBL9687496 | 0.79 | GPR119 (0.53) | GPR119PDE3BPDE3AHRH3TNNC1 | |
| SCHEMBL7298045 | 0.77 | GPR119 (0.63) | GPR119PDE3BPDE3APDE4BSMN1; SMN2 | |
| SCHEMBL7296347 | 0.75 | GPR119 (0.49) | GPR119KDM4EALDH1A1PDE3BPDE3A | |
| SCHEMBL7298414 | 0.73 | GPR119 (0.51) | GPR119MAPTPDE3BPDE3AHRH3 | |
| SCHEMBL9686166 | 0.72 | GPR119 (0.55) | GPR119ALDH1A1PDE3BPDE3APDE4A | |
| SCHEMBL9687194 | 0.72 | PDE3B (0.54) | GPR119PDE3BPDE3APDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |