Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SLC2A1 | P11166 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 3/20 | 0.41 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.32 |
| ▸ | SPHK1 | Q9NYA1 | 1/20 | 0.31 |
| ▸ | CSNK1E | P49674 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326841 | 0.88 | SLC2A1 (0.43) | SLC2A1CA2OPRM1SPHK1CSNK1E | |
| SCHEMBL7293488 | 0.84 | CA2 (0.39) | CA2SPHK1 | |
| SCHEMBL9677956 | 0.82 | — | — | |
| SCHEMBL9767007 | 0.77 | NR1I2 (0.32) | — | |
| SCHEMBL7326578 | 0.76 | ALDH1A1 (0.38) | — | |
| SCHEMBL9803456 | 0.75 | GLS2 (0.34) | — | |
| SCHEMBL9745100 | 0.75 | — | — | |
| SCHEMBL8985039 | 0.75 | GPR84 (0.32) | — | |
| SCHEMBL8985079 | 0.75 | GPR84 (0.32) | — | |
| SCHEMBL9327549 | 0.74 | SMPD1 (0.43) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 16 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | claimed |
| US-5541221-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0637240-A1 | PHARMACEUTICAL COMPOSITIONS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES FOR INHIBITING BONE LOSS | ALLERGAN, INC. (US) | 1995-02-08 | — | — | EP | disclosed |
| US-5387606-A | Pharmaceutical compositions and method for administering 3 and 4-substituted 2(5H)-furanones to a mammal for inhibiting bone loss | ALLERGAN, INC. (US) | 1995-02-07 | — | — | US | disclosed |
| US-5376676-A | Process of using anti-inflammatory furanones as selective calcium channel inhibitors | ALLERGAN, INC. (US) | 1994-12-27 | — | — | US | disclosed |
| US-5322953-A | Antiinflammatory agents; intermediates for 2-furanone compounds | ALLERGAN, INC. (US) | 1994-06-21 | — | — | US | disclosed |
| US-5298633-A | Silane intermediates | ALLERGAN, INC. (US) | 1994-03-29 | — | — | US | disclosed |
| US-5268387-A | Containing ester or carbamate group | ALLERGAN, INC. (US) | 1993-12-07 | — | — | US | disclosed |
| WO-1993021915-A1 | PHARMACEUTICAL COMPOSITIONS FOR INHIBITING BONE LOSS CONTAINING 3 AND 4-SUBSTITUTED 2(5H)-FURANONES | ALLERGAN, INC. (US) | 1993-11-11 | — | — | WO | disclosed |
| US-5171863-A | 2-trialkylsily-4-substituted furan derivatives | ALLERGAN, INC. (US) | 1992-12-15 | — | — | US | disclosed |
| US-5169963-A | Di-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega alkanedioates and N,N-bis-(5-hydroxy-2(5H)2-oxo-4-furyl)alkylmethyl-alpha,omega-dialkanoic acid amides as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-12-08 | — | — | US | disclosed |
| US-5089485-A | ANTI-INFLAMMATORY FURANONES | ALLERGAN, INC. (US) | 1992-02-18 | — | — | US | disclosed |
| US-5082954-A | Intermediates and processes for preparing 4-substituted 2-5(H)-furanones as anti-inflammatory agents | ALLERGAN, INC. (US) | 1992-01-21 | — | — | US | disclosed |
| US-5045564-A | Calcium channel antagonists | ALLERGAN, INC. (US) | 1991-09-03 | — | — | US | disclosed |
| EP-0372940-A2 | Anti-inflammatory 2-furanones | ALLERGAN, INC (US) | 1990-06-13 | — | — | EP | disclosed |
| EP-0369811-A2 | Anti-inflammatory furanones | ALLERGAN, INC (US) | 1990-05-23 | — | — | EP | disclosed |