Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CTSK | P43235 | 6/20 | 0.56 |
| ▸ | CTSB | P07858 | 3/20 | 0.56 |
| ▸ | CTSL | P07711 | 3/20 | 0.51 |
| ▸ | CTSS | P25774 | 2/20 | 0.51 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.50 |
| ▸ | CASP3 | P42574 | 4/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.49 |
| ▸ | CASP1 | P29466 | 2/20 | 0.49 |
| ▸ | CASP7 | P55210 | 2/20 | 0.49 |
| ▸ | CASP9 | P55211 | 1/20 | 0.49 |
| ▸ | CASP4 | P49662 | 1/20 | 0.48 |
| ▸ | REN | P00797 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9215248 | 0.94 | CTSK (0.53) | CTSKCTSBPSMB5CASP3SYK | |
| SCHEMBL7886933 | 0.94 | CTSK (0.53) | CTSKCTSBCTSLCTSSPSMB5 | |
| SCHEMBL7886440 | 0.89 | CTSK (0.52) | CTSKCTSBCTSLCTSSPSMB5 | |
| SCHEMBL7304605 | 0.89 | HTT (0.46) | CTSKCTSBCTSLCTSSPSMB5 | |
| SCHEMBL8653583 | 0.88 | CTSK (0.71) | CTSKCTSBCTSLCTSS | |
| SCHEMBL31326056 | 0.88 | CTSK (0.51) | CTSKCTSBPSMB5CASP3SYK | |
| SCHEMBL31326055 | 0.88 | CTSK (0.51) | CTSKCTSBPSMB5CASP3SYK | |
| SCHEMBL7884623 | 0.87 | CASP3 (0.57) | CTSKCTSBCTSLCTSSCASP3 | |
| SCHEMBL20740990 | 0.87 | CASP3 (0.54) | CTSKCTSBCTSLCTSSPSMB5 | |
| SCHEMBL19015971 | 0.87 | CASP3 (0.54) | CTSKCTSBCTSLCTSSPSMB5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |