Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 8/20 | 0.48 |
| ▸ | EDNRB | P24530 | 6/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.39 |
| ▸ | MAPT | P10636 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.38 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.38 |
| ▸ | PPARG | P37231 | 1/20 | 0.38 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | PKM | P14618 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7303677 | 0.93 | EDNRA (0.48) | EDNRAEDNRBALDH1A1GAAHPGD | |
| SCHEMBL9423499 | 0.84 | CYP3A4 (0.42) | KDM4EMAPTALDH1A1GAAHPGD | |
| SCHEMBL9495260 | 0.81 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL7302650 | 0.80 | EDNRA (0.58) | EDNRAEDNRB | |
| SCHEMBL7304221 | 0.76 | ALDH1A1 (0.41) | EDNRAEDNRBMAPTALDH1A1GAA | |
| SCHEMBL9044922 | 0.73 | EDNRA (0.74) | EDNRAEDNRB | |
| SCHEMBL9052684 | 0.73 | EDNRA (0.68) | EDNRAEDNRB | |
| SCHEMBL7303398 | 0.73 | PKM (0.51) | KDM4EALDH1A1HPGDCYP3A4PPARG | |
| SCHEMBL9423450 | 0.71 | EDNRA (0.60) | EDNRAEDNRBKDM4ESMN1; SMN2 | |
| SCHEMBL9046585 | 0.71 | EDNRA (0.68) | EDNRAEDNRBPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | claimed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | claimed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |