Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PKM | P14618 | 1/20 | 0.51 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.50 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.41 |
| ▸ | KDM1A | O60341 | 1/20 | 0.41 |
| ▸ | MAOA | P21397 | 1/20 | 0.41 |
| ▸ | CRHBP | P24387 | 1/20 | 0.41 |
| ▸ | CRHR2 | Q13324 | 1/20 | 0.41 |
| ▸ | SLC22A12 | Q96S37 | 2/20 | 0.41 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.41 |
| ▸ | PPARG | P37231 | 4/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.39 |
| ▸ | CCR4 | P51679 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304221 | 0.88 | ALDH1A1 (0.41) | PKMRXFP1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL9423499 | 0.88 | CYP3A4 (0.42) | PKMRXFP1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL7293909 | 0.78 | ESR1 (0.44) | PKMALDH1A1LMNAMEN1KMT2A | |
| SCHEMBL9047803 | 0.74 | PKM (0.55) | PKMRXFP1ALDH1A1L3MBTL1LMNA | |
| SCHEMBL7303677 | 0.73 | EDNRA (0.48) | ALDH1A1MEN1KMT2AHPGDTSHR | |
| SCHEMBL7303684 | 0.73 | EDNRA (0.48) | PKMALDH1A1LMNAHTTSMN1; SMN2 | |
| SCHEMBL7294559 | 0.68 | CA1 (0.36) | ALDH1A1LMNAKMT2ASMN1; SMN2CYP3A4 | |
| SCHEMBL23118291 | 0.67 | PGR (0.48) | LMNAHTTMEN1KMT2ASMN1; SMN2 | |
| SCHEMBL9046229 | 0.67 | KDM1A (0.53) | PKMLMNAKDM1AMAOACRHBP | |
| SCHEMBL7303769 | 0.67 | EDNRA (0.55) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |