Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EEF2K | O00418 | 2/20 | 0.36 |
| ▸ | MMP13 | P45452 | 7/20 | 0.35 |
| ▸ | POLB | P06746 | 1/20 | 0.35 |
| ▸ | MMP1 | P03956 | 4/20 | 0.34 |
| ▸ | MMP2 | P08253 | 4/20 | 0.34 |
| ▸ | MMP3 | P08254 | 4/20 | 0.34 |
| ▸ | MMP7 | P09237 | 4/20 | 0.34 |
| ▸ | MMP9 | P14780 | 4/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | GPR119 | Q8TDV5 | 1/20 | 0.33 |
| ▸ | F2 | P00734 | 1/20 | 0.33 |
| ▸ | F2R | P25116 | 1/20 | 0.33 |
| ▸ | PSMB8 | P28062 | 1/20 | 0.33 |
| ▸ | PSMB5 | P28074 | 1/20 | 0.33 |
| ▸ | F10 | P00742 | 1/20 | 0.33 |
| ▸ | ADAMTS4 | O75173 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8720126 | 0.90 | EEF2K (0.44) | EEF2KMMP13POLBMMP1MMP2 | |
| SCHEMBL7298351 | 0.87 | F2 (0.43) | MMP13POLBMMP2MMP9HSD17B10 | |
| SCHEMBL7295250 | 0.86 | L3MBTL1 (0.39) | MMP13POLBMMP1MMP2MMP3 | |
| SCHEMBL7303910 | 0.85 | ACACB (0.43) | F2F10 | |
| SCHEMBL7301032 | 0.83 | TSHR (0.36) | HSD17B10GPR119F2F10 | |
| SCHEMBL7298089 | 0.82 | MMP13 (0.34) | MMP13MMP1MMP2MMP3MMP7 | |
| SCHEMBL7296038 | 0.81 | CYP1A2 (0.31) | F10 | |
| SCHEMBL27380499 | 0.81 | CYP1A2 (0.31) | F10 | |
| SCHEMBL7304125 | 0.81 | CA12 (0.36) | MMP13POLBMMP1MMP2MMP9 | |
| SCHEMBL8947611 | 0.81 | CA12 (0.36) | MMP13POLBMMP1MMP2MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0559046-B1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | HOFFMANN LA ROCHE (CH) | 2001-07-11 | — | — | EP | disclosed |
| EP-0559046-A1 | N-amidinopiperidinyl(3/4)- or N-amidino-1,4-Oxazinyl(2)-substituted sulfonamides, process for their preparation and use as thrombin inhibitors | F.HOFFMANN-LA ROCHE & CO. AKTIENGESELLSCHAFT (CH) | 1993-09-08 | — | — | EP | disclosed |