Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TNF | P01375 | 10/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | GPR139 | Q6DWJ6 | 2/20 | 0.37 |
| ▸ | ELANE | P08246 | 1/20 | 0.35 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.35 |
| ▸ | CNR1 | P21554 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.34 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.34 |
| ▸ | GAA | P10253 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7313887 | 0.88 | CYP2C19 (0.46) | KDM4EHSD17B10GPR139ELANECYP2C9 | |
| SCHEMBL7310513 | 0.87 | KDM4E (0.40) | TNFKDM4EHSD17B10GPR139TBXAS1 | |
| SCHEMBL6473965 | 0.84 | KDM4E (0.39) | TNFKDM4EHSD17B10GPR139TBXAS1 | |
| SCHEMBL6474507 | 0.78 | KDM4E (0.41) | TNFKDM4EHSD17B10TBXAS1GAA | |
| SCHEMBL7301560 | 0.73 | CYP2C19 (0.48) | KDM4EHSD17B10GPR139CYP2C9CYP2C19 | |
| SCHEMBL6474348 | 0.71 | ALDH1A1 (0.44) | TNFKDM4EHSD17B10GPR139CYP2C19 | |
| SCHEMBL6474544 | 0.71 | CYP2C19 (0.47) | KDM4EHSD17B10GPR139CYP2C9CYP2C19 | |
| SCHEMBL7307719 | 0.66 | SCN5A (0.48) | KDM4EELANE | |
| SCHEMBL5701486 | 0.64 | ELANE (0.57) | KDM4EHSD17B10ELANEGAA | |
| SCHEMBL6474360 | 0.64 | CYP2C19 (0.50) | KDM4EHSD17B10GPR139CYP2C9CYP2C19 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0854140-B1 | Vitronectin receptor antagonists, their production and their use | SANOFI AVENTIS DEUTSCHLAND (DE) | 2013-11-06 | — | — | EP | disclosed |
| EP-0854140-A2 | Vitronectin receptor antagonists, their production and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1998-07-22 | — | — | EP | disclosed |