Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | OPRM1 | P35372 | 1/20 | 0.50 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.50 |
| ▸ | OPRK1 | P41145 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 3/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | RAB9A | P51151 | 1/20 | 0.46 |
| ▸ | CA2 | P00918 | 1/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.44 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.44 |
| ▸ | MEN1 | O00255 | 2/20 | 0.42 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7280361 | 0.83 | NPC1 (0.53) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL7322799 | 0.83 | NPC1 (0.53) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL7274173 | 0.82 | KMT2A (0.51) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL7539929 | 0.76 | NPC1 (0.52) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL7360519 | 0.76 | KDM4E (0.47) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL7539925 | 0.76 | NPC1 (0.52) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL7305617 | 0.76 | HIF1A (0.49) | ALDH1A1SMN1; SMN2NPC1POLBRAB9A | |
| SCHEMBL5879498 | 0.76 | ALDH1A1 (0.50) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL5879436 | 0.76 | ALDH1A1 (0.50) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT | |
| SCHEMBL7297904 | 0.76 | KDM4E (0.49) | ALDH1A1CYP1A2SMN1; SMN2CYP2D6MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5063208-A | Cardiovascular disorders, vision defects | ABBOTT LABORATORIES (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0410260-A2 | Peptidyl aminodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-01-30 | — | — | EP | disclosed |