Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 1/20 | 0.51 |
| ▸ | CA2 | P00918 | 2/20 | 0.51 |
| ▸ | GPR132 | Q9UNW8 | 1/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.49 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.46 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | TSHR | P16473 | 1/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.46 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.46 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.46 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | MME | P08473 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305859 | 0.91 | KMT2A (0.52) | KMT2AGPR132ALDH1A1CYP2D6MAPT | |
| SCHEMBL7274220 | 0.88 | ALDH1A1 (0.49) | KMT2ACA2GPR132ALDH1A1NPC1 | |
| SCHEMBL27303428 | 0.88 | ALDH1A1 (0.49) | KMT2ACA2GPR132ALDH1A1NPC1 | |
| SCHEMBL5879436 | 0.82 | ALDH1A1 (0.50) | KMT2ACA2ALDH1A1NPC1POLB | |
| SCHEMBL5879498 | 0.82 | ALDH1A1 (0.50) | KMT2ACA2ALDH1A1NPC1POLB | |
| SCHEMBL6656758 | 0.82 | ALDH1A1 (0.50) | KMT2ACA2ALDH1A1NPC1POLB | |
| SCHEMBL7306601 | 0.82 | ALDH1A1 (0.48) | KMT2AALDH1A1NPC1RAB9AKDM4E | |
| SCHEMBL7303820 | 0.82 | OPRM1 (0.50) | KMT2ACA2ALDH1A1NPC1POLB | |
| SCHEMBL19290059 | 0.81 | ALDH1A1 (0.49) | KMT2ACA2ALDH1A1NPC1POLB | |
| SCHEMBL7305790 | 0.81 | CA2 (0.55) | KMT2ACA2ALDH1A1NPC1POLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5491132-A | HYPOTENSIVE AGENT | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1996-02-13 | — | — | US | disclosed |
| EP-0476515-A1 | New amino acid derivatives, a process for the preparation thereof and pharmaceutical composition comprising the same | FUJISAWA PHARMACEUTICAL CO., LTD. (JP) | 1992-03-25 | — | — | EP | disclosed |
| US-5063208-A | Cardiovascular disorders, vision defects | ABBOTT LABORATORIES (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0410260-A2 | Peptidyl aminodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-01-30 | — | — | EP | disclosed |