Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | BCHE | P06276 | 4/20 | 0.39 |
| ▸ | ACHE | P22303 | 4/20 | 0.39 |
| ▸ | TSHR | P16473 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | POLB | P06746 | 2/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.39 |
| ▸ | ALOX5 | P09917 | 2/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.39 |
| ▸ | MEN1 | O00255 | 2/20 | 0.39 |
| ▸ | MMP2 | P08253 | 1/20 | 0.39 |
| ▸ | MMP9 | P14780 | 1/20 | 0.39 |
| ▸ | MMP8 | P22894 | 1/20 | 0.39 |
| ▸ | MMP14 | P50281 | 1/20 | 0.39 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.38 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7204613 | 0.80 | CYP4F2 (0.46) | MTNR1AKMT2ATSHRLMNAPOLB | |
| SCHEMBL6044544 | 0.79 | MAPT (0.51) | KMT2ATSHRLMNAPOLBTP53 | |
| SCHEMBL19418888 | 0.75 | CYP3A4 (0.40) | KMT2AACHELMNAPOLBTP53 | |
| SCHEMBL9254561 | 0.74 | CYP4F2 (0.46) | KMT2ATSHRLMNAPOLBL3MBTL1 | |
| SCHEMBL11571633 | 0.74 | CA2 (0.48) | FFAR1L3MBTL1SMN1; SMN2NPC1RAB9A | |
| SCHEMBL17591779 | 0.73 | KMT2A (0.41) | MTNR1AKMT2AACHELMNAPOLB | |
| SCHEMBL19410273 | 0.73 | CYP19A1 (0.55) | KMT2ACYP3A4MAPT | |
| SCHEMBL1519271 | 0.73 | CYP4F2 (0.50) | TSHRLMNAPOLBL3MBTL1NPSR1 | |
| SCHEMBL5579264 | 0.71 | KMT2A (0.45) | KMT2ABCHEACHETSHRLMNA | |
| SCHEMBL8121091 | 0.70 | MTNR1A (0.45) | MTNR1AKMT2ATSHRLMNAPOLB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0678503-B1 | Delta-amino-gamma-hydroxy-omega-aryl alkanoic acid amides with enzyme especially renin inhibiting activities | NOVARTIS AG (CH) | 1999-09-01 | — | — | EP | disclosed |
| EP-0678503-A1 | Delta-amino-gamma-hydroxy-omega-aryl alkanoic acid amides with enzyme especially renin inhibiting activities | CIBA-GEIGY AG (CH) | 1995-10-25 | — | — | EP | disclosed |