Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK1 | P28482 | 2/20 | 0.51 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | MAOB | P27338 | 9/20 | 0.51 |
| ▸ | MAOA | P21397 | 4/20 | 0.46 |
| ▸ | RAB9A | P51151 | 5/20 | 0.43 |
| ▸ | NPC1 | O15118 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.43 |
| ▸ | LMNA | P02545 | 2/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | NOS2 | P35228 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.40 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.39 |
| ▸ | FKBP1A | P62942 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6165864 | 0.77 | ALDH1A1 (0.78) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL11379943 | 0.77 | MAOB (0.50) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL28446570 | 0.75 | MAPK1 (0.64) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL22162810 | 0.73 | MEN1 (0.64) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL6945487 | 0.73 | MAPK1 (0.49) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL6939958 | 0.73 | MEN1 (0.53) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL30969596 | 0.73 | PDE5A (0.54) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL6942370 | 0.73 | NOS2 (0.56) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL108699 | 0.72 | NOS2 (0.66) | MAPK1ALDH1A1MAOBMAOARAB9A | |
| SCHEMBL22404289 | 0.72 | CLK4 (0.50) | MAPK1ALDH1A1RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |