Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | RAB9A | P51151 | 6/20 | 0.47 |
| ▸ | NPC1 | O15118 | 5/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 5/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | KLKB1 | P03952 | 1/20 | 0.44 |
| ▸ | KLK1 | P06870 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.43 |
| ▸ | MEN1 | O00255 | 4/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | MAPT | P10636 | 3/20 | 0.43 |
| ▸ | HTT | P42858 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
| ▸ | USP2 | O75604 | 1/20 | 0.42 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.42 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301901 | 0.83 | DHPS (0.53) | RAB9ANPC1SMN1; SMN2ABCB1ABCC1 | |
| SCHEMBL28568819 | 0.78 | DHPS (0.59) | ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL4061462 | 0.77 | DHPS (0.49) | RAB9ANPC1SMN1; SMN2ALDH1A1MEN1 | |
| SCHEMBL7483960 | 0.77 | HTT (0.48) | SMN1; SMN2KDM4EALDH1A1MAPTHTT | |
| SCHEMBL8073660 | 0.77 | KDM4E (0.44) | RAB9ANPC1SMN1; SMN2ABCB1ABCC1 | |
| SCHEMBL8070472 | 0.77 | XPO1 (0.58) | RAB9ANPC1SMN1; SMN2ABCB1ABCC1 | |
| SCHEMBL1937757 | 0.77 | EDNRA (0.49) | — | |
| SCHEMBL5632966 | 0.76 | HTT (0.47) | SMN1; SMN2ALDH1A1MEN1KMT2AMAPT | |
| SCHEMBL5631066 | 0.74 | HTT (0.46) | ALDH1A1HTTMAPK1HSD17B10TSHR | |
| SCHEMBL8070339 | 0.74 | RPS6KB2 (0.57) | RAB9ANPC1SMN1; SMN2ABCB1ABCC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |