Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DHPS | P49366 | 14/20 | 0.53 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | RAB9A | P51151 | 2/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.47 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.45 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.45 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.45 |
| ▸ | RPS6KB2 | Q9UBS0 | 1/20 | 0.44 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304349 | 0.83 | RAB9A (0.47) | NPC1RAB9ASMN1; SMN2ABCB1ABCC1 | |
| SCHEMBL9423667 | 0.78 | NPC1 (0.52) | DHPSNPC1RAB9ASMN1; SMN2ALDH1A1 | |
| SCHEMBL7837861 | 0.78 | ALDH1A1 (0.46) | DHPSABCB1ABCC1ABCG2ALDH1A1 | |
| SCHEMBL7837858 | 0.78 | ALDH1A1 (0.46) | DHPSABCB1ABCC1ABCG2ALDH1A1 | |
| SCHEMBL7303389 | 0.78 | DHPS (0.81) | DHPSALDH1A1 | |
| SCHEMBL7300163 | 0.77 | EDNRA (0.63) | DHPS | |
| SCHEMBL4071996 | 0.77 | DHPS (0.67) | DHPSNPC1RAB9ASMN1; SMN2 | |
| SCHEMBL7204802 | 0.77 | DHPS (0.57) | DHPSSMN1; SMN2ALDH1A1 | |
| SCHEMBL5632471 | 0.77 | DHPS (0.57) | DHPSSMN1; SMN2ALDH1A1 | |
| SCHEMBL7293181 | 0.77 | DHPS (0.59) | DHPS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0526708-B1 | Sulfonamide, preparation and use thereof as medicine and intermediate | HOFFMANN LA ROCHE (CH) | 2000-10-18 | — | — | EP | disclosed |
| US-5292740-A | Sulfonamides | HOFFMANN-LA ROCHE INC. (US) | 1994-03-08 | — | — | US | disclosed |
| EP-0526708-A1 | Sulfonamide, preparation and use thereof as medicine and intermediate | F. HOFFMANN-LA ROCHE AG (CH) | 1993-02-10 | — | — | EP | disclosed |