Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | XPO1 | O14980 | 3/20 | 0.58 |
| ▸ | IKBKB | O14920 | 1/20 | 0.53 |
| ▸ | CHUK | O15111 | 1/20 | 0.53 |
| ▸ | JUN | P05412 | 1/20 | 0.53 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.53 |
| ▸ | FLT3 | P36888 | 1/20 | 0.53 |
| ▸ | NFKB2 | Q00653 | 1/20 | 0.53 |
| ▸ | RELA | Q04206 | 1/20 | 0.53 |
| ▸ | ADORA3 | P0DMS8 | 2/20 | 0.48 |
| ▸ | RPS6KB2 | Q9UBS0 | 2/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 6/20 | 0.46 |
| ▸ | MAPT | P10636 | 5/20 | 0.46 |
| ▸ | LMNA | P02545 | 4/20 | 0.46 |
| ▸ | L3MBTL1 | Q9Y468 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 3/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.46 |
| ▸ | HTT | P42858 | 2/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8070655 | 0.84 | XPO1 (0.58) | XPO1IKBKBCHUKJUNNFKB1 | |
| SCHEMBL8070557 | 0.82 | MAPT (0.43) | XPO1IKBKBCHUKJUNNFKB1 | |
| SCHEMBL8070477 | 0.79 | MAPT (0.45) | XPO1RPS6KB2KDM4EMAPTLMNA | |
| SCHEMBL8059496 | 0.79 | PDE5A (0.42) | XPO1RPS6KB2KDM4EMAPTLMNA | |
| SCHEMBL8070339 | 0.78 | RPS6KB2 (0.57) | XPO1ADORA3RPS6KB2KDM4EMAPT | |
| SCHEMBL8073660 | 0.78 | KDM4E (0.44) | XPO1ADORA3RPS6KB2KDM4EMAPT | |
| SCHEMBL7304349 | 0.77 | RAB9A (0.47) | XPO1NFKB1NFKB2RELAADORA3 | |
| SCHEMBL6025660 | 0.76 | ALDH1A1 (0.51) | KDM4EMAPTLMNAALDH1A1MEN1 | |
| SCHEMBL28320598 | 0.75 | ALDH1A1 (0.50) | KDM4EMAPTLMNAALDH1A1MEN1 | |
| SCHEMBL16011941 | 0.75 | ALDH1A1 (0.53) | KDM4EMAPTLMNAALDH1A1MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-6150372-A | IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES; BLOCKING INTRACELLULAR SIGNAL TRANSDUCTION AND ACTIVATION OF TRANSCRIPTION FACTORS; KINASE INHIBITORS; ANTIARTHRITIC, ISCHEMIC AGENTS, MULTIPLE SCLEROSIS, TRANSPLANT REJECTION | SIGNAL PHARMACEUTICALS, INC. (US) | 2000-11-21 | — | — | US | disclosed |
| US-5939421-A | TREATMENT OF IMMUNOINFLAMMATORY AND AUTOIMMUNE DISEASES SUCH AS RHEUMATOID ARTHRITIS, TRANSPLANT REJECTION; INHIBIT KINASE(S) THAT REGULATE ACTIVATION OF TRANSCRIPTION FACTORS TO PREVENT PRODUCTION OF INFLAMMATORY PROTEINS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-08-17 | — | — | US | disclosed |
| WO-1999001441-A1 | QUINAZOLINE ANALOGS AND RELATED COMPOUNDS AND METHODS FOR TREATING INFLAMMATORY CONDITIONS | SIGNAL PHARMACEUTICALS, INC. (US) | 1999-01-14 | — | — | WO | disclosed |