Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 8/20 | 0.76 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.76 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.76 |
| ▸ | GABRA3 | P34903 | 7/20 | 0.76 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.76 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.76 |
| ▸ | GABRA6 | Q16445 | 3/20 | 0.76 |
| ▸ | MEN1 | O00255 | 2/20 | 0.76 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.76 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.50 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.44 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.44 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8768403 | 1.00 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7394197 | 0.94 | GABRG2 (0.67) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7392298 | 0.91 | GABRG2 (0.75) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL10808364 | 0.88 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL7328484 | 0.88 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL10811227 | 0.88 | GABRA1 (0.59) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL10805526 | 0.88 | GABRA1 (0.59) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL10629894 | 0.88 | GABRA1 (0.62) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| SCHEMBL10813951 | 0.87 | GABRG2 (0.58) | GABRG2GABRB3GABRA5GABRA3GABRA1 | |
| Bretazenil SCHEMBL124595 | 0.86 | GABRG2 (1.00) | GABRG2GABRB3GABRA5GABRA3GABRA1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 29 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0488044-B1 | An imidazobenzodiazepin for treating sleep disorders | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | claimed |
| EP-0331871-B1 | Imidazobenzodiazepine with antipsychotic activity | HOFFMANN LA ROCHE (CH) | 1993-12-01 | — | — | EP | claimed |
| US-5221672-A | Therapy for sleep disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-06-22 | — | — | US | claimed |
| EP-0488044-A1 | An imidazobenzodiazepin for treating sleep disorders | F. HOFFMANN-LA ROCHE AG (CH) | 1992-06-03 | — | — | EP | claimed |
| US-4861772-A | Method and composition to treat panic syndrome | HOFFMANN-LA ROCHE INC. (US) | 1989-08-29 | — | — | US | claimed |
| EP-0100906-B1 | TRI- AND TETRACYCLIC IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-1-CARBOXYLIC-ACID DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-05-13 | — | — | EP | claimed |
| US-4489003-A | ANTICONVULSANTS, TRANQUILLIZERS | HOFFMANN-LA ROCHE INC. (US) | 1984-12-18 | — | — | US | claimed |
| EP-0100906-A2 | Tri- and tetracyclic imidazo(1,5-a)(1,4)benzodiazepin-1-carboxylic-acid derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | claimed |
| US-4353827-A | ANTICONVULSIVE, ANXIOLYTIC | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | claimed |
| EP-0488044-B1 | An imidazobenzodiazepin for treating sleep disorders | HOFFMANN LA ROCHE (CH) | 1996-02-14 | — | — | EP | disclosed |
| EP-0331871-B1 | Imidazobenzodiazepine with antipsychotic activity | HOFFMANN LA ROCHE (CH) | 1993-12-01 | — | — | EP | disclosed |
| US-5221672-A | Therapy for sleep disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-06-22 | — | — | US | disclosed |
| US-5221672-A | Therapy for sleep disorders | HOFFMANN-LA ROCHE INC. (US) | 1993-06-22 | — | — | US | disclosed |
| EP-0285837-B1 | IMIDAZODIAZEPIN DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 1992-07-08 | — | — | EP | disclosed |
| US-4775671-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0100906-B1 | TRI- AND TETRACYCLIC IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-1-CARBOXYLIC-ACID DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-05-13 | — | — | EP | disclosed |
| EP-0150040-A2 | Imidazodiazepine derivatives | F. HOFFMANN-LA ROCHE AG (CH) | 1985-07-31 | — | — | EP | disclosed |
| US-4489003-A | ANTICONVULSANTS, TRANQUILLIZERS | HOFFMANN-LA ROCHE INC. (US) | 1984-12-18 | — | — | US | disclosed |
| EP-0100906-A2 | Tri- and tetracyclic imidazo(1,5-a)(1,4)benzodiazepin-1-carboxylic-acid derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | disclosed |
| US-4353827-A | ANTICONVULSIVE, ANXIOLYTIC | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | disclosed |