Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GABRG2 | P18507 | 8/20 | 0.59 |
| ▸ | GABRB3 | P28472 | 8/20 | 0.59 |
| ▸ | GABRA5 | P31644 | 7/20 | 0.59 |
| ▸ | GABRA1 | P14867 | 7/20 | 0.59 |
| ▸ | GABRA3 | P34903 | 6/20 | 0.59 |
| ▸ | GABRA2 | P47869 | 5/20 | 0.59 |
| ▸ | GABRA6 | Q16445 | 4/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.59 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | GABRA4 | P48169 | 3/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7433706 | 0.94 | GABRA1 (0.52) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL8768353 | 0.94 | GABRA1 (0.52) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL9372231 | 0.91 | GABRG2 (0.58) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10625617 | 0.89 | GABRG2 (0.56) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL8872563 | 0.88 | GABRA1 (0.56) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10808364 | 0.88 | GABRG2 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10629894 | 0.88 | GABRA1 (0.62) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL7304650 | 0.88 | GABRG2 (0.76) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10805526 | 0.88 | GABRA1 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 | |
| SCHEMBL10811227 | 0.88 | GABRA1 (0.59) | GABRG2GABRB3GABRA5GABRA1GABRA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 26 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0100906-B1 | TRI- AND TETRACYCLIC IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-1-CARBOXYLIC-ACID DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-05-13 | — | — | EP | claimed |
| US-4489003-A | ANTICONVULSANTS, TRANQUILLIZERS | HOFFMANN-LA ROCHE INC. (US) | 1984-12-18 | — | — | US | claimed |
| EP-0100906-A2 | Tri- and tetracyclic imidazo(1,5-a)(1,4)benzodiazepin-1-carboxylic-acid derivatives | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1984-02-22 | — | — | EP | claimed |
| US-4353827-A | ANTICONVULSIVE, ANXIOLYTIC | HOFFMANN-LA ROCHE INC. (US) | 1982-10-12 | — | — | US | claimed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | claimed |
| EP-0672666-B1 | Imidazodiazepins | HOFFMANN LA ROCHE (CH) | 2001-07-25 | — | — | EP | disclosed |
| EP-0451626-B1 | The use of benzodiazepine compounds for preparing a pharmaceutical composition against CNS disorders related to the excitatory aminoacids | NEUROSEARCH AS (DK) | 1997-09-10 | — | — | EP | disclosed |
| US-5665718-A | ANXIOLYTIC, ANTICONVULSANT, MUSCLE RELAXANT, SEDATIVE, HYPNOTIC AGENTS | HOFFMANN-LA ROCHE INC. (US) | 1997-09-09 | — | — | US | disclosed |
| US-5270306-A | Method of antagonizing excitatory amino acids by administration of imidazobenzodiazepine compounds | NEUROSEARCH A/S (DK) | 1993-12-14 | — | — | US | disclosed |
| EP-0451626-A2 | The use of benzodiazepine compounds for preparing a pharmaceutical composition against CNS disorders related to the excitatory aminoacids | NEUROSEARCH A/S (DK) | 1991-10-16 | — | — | EP | disclosed |
| US-4775671-A | ANXIOLYTIC AGENTS, ANTICONVULSANTS, SEDATIVES, MUSCLE RELAXANTS | HOFFMANN-LA ROCHE INC. (US) | 1988-10-04 | — | — | US | disclosed |
| EP-0100906-B1 | TRI- AND TETRACYCLIC IMIDAZO(1,5-A)(1,4)BENZODIAZEPIN-1-CARBOXYLIC-ACID DERIVATIVES | F. HOFFMANN-LA ROCHE & CO. Aktiengesellschaft (CH) | 1987-05-13 | — | — | EP | disclosed |
| US-4346032-A | ANTIDOTES TO OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346034-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346035-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346036-A | ALKYLATION; AMIDATION; TRANQUILIZER ANTAGONIST | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346030-A | ANTIDOTES FOR OVERDOSES OF BENZODIAZEPINE TRANQUILIZERS | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346031-A | Process for preparing imidazodiazepines | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4346033-A | Thienodiazepinone and benzodiazepinone intermediates | HOFFMANN-LA ROCHE INC. (US) | 1982-08-24 | — | — | US | disclosed |
| US-4316839-A | Imidazodiazepine derivatives | HOFFMAN-LA ROCHE INC. (US) | 1982-02-23 | — | — | US | disclosed |