Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | NR3C2 | P08235 | 8/20 | 0.37 |
| ▸ | NR3C1 | P04150 | 7/20 | 0.37 |
| ▸ | PGR | P06401 | 1/20 | 0.37 |
| ▸ | HSD11B1 | P28845 | 1/20 | 0.36 |
| ▸ | CCR2 | P41597 | 3/20 | 0.35 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.34 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.34 |
| ▸ | POLB | P06746 | 2/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.34 |
| ▸ | AKR1C2 | P52895 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7299169 | 0.80 | LMNA (0.58) | LMNANR3C2NR3C1PGRHSD11B1 | |
| SCHEMBL8544144 | 0.80 | LMNA (0.53) | LMNANR3C2NR3C1CCR2POLB | |
| SCHEMBL7305178 | 0.80 | LMNA (0.58) | LMNANR3C2NR3C1PGRHSD11B1 | |
| SCHEMBL8546477 | 0.78 | LMNA (0.51) | LMNAMEN1KMT2A | |
| SCHEMBL8542630 | 0.77 | LMNA (0.62) | LMNAL3MBTL1POLBMEN1KMT2A | |
| SCHEMBL8543754 | 0.75 | LMNA (0.64) | LMNANR3C2NR3C1L3MBTL1POLB | |
| SCHEMBL7311376 | 0.73 | LMNA (0.54) | LMNA | |
| SCHEMBL8548928 | 0.71 | LMNA (0.60) | LMNANR3C2NR3C1PGRL3MBTL1 | |
| SCHEMBL7298261 | 0.71 | LMNA (0.58) | LMNANR3C2NR3C1PGRPOLB | |
| SCHEMBL7300845 | 0.71 | LMNA (0.58) | LMNANR3C2NR3C1POLBHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0666260-B1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1999-08-04 | — | — | EP | disclosed |
| US-5550125-A | BRAIN DISORDERS | SYNTHELABO (FR) | 1996-08-27 | — | — | US | disclosed |
| EP-0666260-A1 | 3-(2-aminoethyl)-4-3-(trifluoromethyl)benzoyl-3,4-dihydro-2H-1,4-benzoxazine derivatives, their preparation and use in therapy | SYNTHELABO (FR) | 1995-08-09 | — | — | EP | disclosed |