Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.61 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP19A1 | P11511 | 4/20 | 0.53 |
| ▸ | POLB | P06746 | 1/20 | 0.53 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.53 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 1/20 | 0.53 |
| ▸ | TBXAS1 | P24557 | 1/20 | 0.53 |
| ▸ | QPCT | Q16769 | 1/20 | 0.53 |
| ▸ | CYP4Z1 | Q86W10 | 1/20 | 0.53 |
| ▸ | QPCTL | Q9NXS2 | 1/20 | 0.53 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.49 |
| ▸ | HMOX2 | P30519 | 1/20 | 0.49 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305090 | 1.00 | HRH4 (0.61) | HRH4CYP1A2CYP19A1POLBCYP3A4 | |
| SCHEMBL9556789 | 1.00 | HRH4 (0.61) | HRH4CYP1A2CYP19A1POLBCYP3A4 | |
| SCHEMBL9556344 | 0.89 | HRH4 (0.58) | HRH4CYP1A2CYP19A1POLBCYP3A4 | |
| SCHEMBL6978364 | 0.87 | CYP19A1 (0.54) | HRH4CYP19A1CYP11B1CYP11B2TBXAS1 | |
| SCHEMBL8532853 | 0.84 | HRH4 (0.60) | HRH4CYP1A2CYP19A1POLBCYP3A4 | |
| SCHEMBL9556665 | 0.84 | HRH4 (0.60) | HRH4AGTR2 | |
| SCHEMBL10772703 | 0.82 | TBXAS1 (0.66) | CYP19A1TBXAS1SMN1; SMN2 | |
| SCHEMBL8536371 | 0.82 | HRH4 (0.58) | HRH4CYP19A1AGTR2 | |
| SCHEMBL11634738 | 0.80 | AGER (0.58) | CYP1A2CYP19A1POLBCYP3A4CYP2D6 | |
| SCHEMBL11286358 | 0.80 | CYP11B1 (0.61) | HRH4CYP1A2CYP19A1POLBCYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5258362-A | Enzyme inhibitors, amides with oxetane ring | ABBOTT LABORATORIES (US) | 1993-11-02 | — | — | US | disclosed |
| US-5063208-A | Cardiovascular disorders, vision defects | ABBOTT LABORATORIES (US) | 1991-11-05 | — | — | US | disclosed |
| EP-0410260-A2 | Peptidyl aminodiol renin inhibitors | ABBOTT LABORATORIES (US) | 1991-01-30 | — | — | EP | disclosed |