Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MBOAT4 | Q96T53 | 1/20 | 0.46 |
| ▸ | SYK | P43405 | 1/20 | 0.42 |
| ▸ | CETP | P11597 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | POLB | P06746 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9326555 | 0.82 | CTSS (0.44) | SYKALDH1A1MAPK1TDP1L3MBTL1 | |
| SCHEMBL20943365 | 0.77 | MBOAT4 (0.46) | MBOAT4CETPALDH1A1CYP3A4TSHR | |
| SCHEMBL20943336 | 0.77 | MBOAT4 (0.46) | MBOAT4CETPALDH1A1CYP3A4TSHR | |
| SCHEMBL20943384 | 0.77 | MBOAT4 (0.46) | MBOAT4SYKCETPALDH1A1CYP3A4 | |
| SCHEMBL20960158 | 0.77 | MBOAT4 (0.46) | MBOAT4SYKCETPALDH1A1CYP3A4 | |
| SCHEMBL17381294 | 0.77 | MBOAT4 (0.46) | MBOAT4CETPALDH1A1CYP3A4TSHR | |
| SCHEMBL29414961 | 0.76 | CETP (0.51) | MBOAT4CETPALDH1A1CYP3A4TSHR | |
| SCHEMBL16419678 | 0.76 | ALDH1A1 (0.48) | MBOAT4SYKCETPALDH1A1CYP3A4 | |
| SCHEMBL16412141 | 0.75 | MBOAT4 (0.45) | MBOAT4CETPALDH1A1CYP3A4TSHR | |
| SCHEMBL27229092 | 0.75 | MBOAT4 (0.42) | MBOAT4SYKCETPALDH1A1CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0575844-B1 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | HOFFMANN LA ROCHE (CH) | 1998-01-21 | — | — | EP | disclosed |
| EP-0575844-A2 | Hydroxamic acid derivatives and pharmaceutical compositions thereof | F. HOFFMANN-LA ROCHE AG (CH) | 1993-12-29 | — | — | EP | disclosed |