Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | REN | P00797 | 9/20 | 0.46 |
| ▸ | CTSS | P25774 | 3/20 | 0.43 |
| ▸ | CTSL | P07711 | 4/20 | 0.43 |
| ▸ | CTSB | P07858 | 3/20 | 0.43 |
| ▸ | CTSK | P43235 | 2/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305274 | 1.00 | REN (0.46) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL7277586 | 0.84 | REN (0.49) | REN | |
| SCHEMBL7277581 | 0.84 | REN (0.49) | REN | |
| SCHEMBL7300500 | 0.83 | REN (0.61) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL7300506 | 0.83 | REN (0.61) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL7269967 | 0.83 | CTSC (0.38) | REN | |
| SCHEMBL7269979 | 0.83 | CTSC (0.38) | REN | |
| SCHEMBL9725854 | 0.82 | REN (0.47) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL7287149 | 0.81 | REN (0.47) | RENCTSSCTSLCTSBCTSK | |
| SCHEMBL7287141 | 0.81 | REN (0.47) | RENCTSSCTSLCTSBCTSK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5459131-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1995-10-17 | — | — | US | disclosed |
| US-5189023-A | Hypotensive agent | AMERICAN CYANAMID COMPANY (US) | 1993-02-23 | — | — | US | disclosed |
| US-5104869-A | Renin inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-04-14 | — | — | US | disclosed |
| EP-0473936-A1 | Renin Inhibitors | AMERICAN CYANAMID COMPANY (US) | 1992-03-11 | — | — | EP | disclosed |