Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 8/20 | 0.50 |
| ▸ | GAA | P10253 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.45 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.39 |
| ▸ | THRB | P10828 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MEN1 | O00255 | 1/20 | 0.38 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.38 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305309 | 1.00 | MAPT (0.50) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL13712657 | 0.82 | EGFR (0.44) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL5091921 | 0.82 | EGFR (0.44) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL5091917 | 0.82 | EGFR (0.44) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL7296409 | 0.82 | MAPT (0.53) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL7296406 | 0.82 | MAPT (0.53) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL10500852 | 0.77 | PTGS2 (0.46) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL15396141 | 0.76 | MAPT (0.48) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL30089102 | 0.76 | ALDH1A1 (0.44) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL22980394 | 0.74 | F2 (0.45) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507650-B1 | Piperidine derivatives, their preparation and their therapeutic application | SYNTHELABO (FR) | 1996-05-22 | — | — | EP | disclosed |
| US-5280030-A | Containing 1-benz(oxazole, thiazole or imidazole)-4-imidazole piperidine compound | SYNTHELABO (FR) | 1994-01-18 | — | — | US | disclosed |
| EP-0507650-A1 | Piperidine derivatives, their preparation and their therapeutic application | SYNTHELABO (FR) | 1992-10-07 | — | — | EP | disclosed |