Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 6/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.40 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7296409 | 1.00 | MAPT (0.53) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL215632 | 0.87 | MAPT (0.69) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL31565026 | 0.85 | LMNA (0.46) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL92088 | 0.85 | LMNA (0.46) | MAPTALDH1A1KMT2ASMN1; SMN2MEN1 | |
| SCHEMBL3170144 | 0.83 | KDM4E (0.57) | MAPTALDH1A1PTGS2KMT2ASMN1; SMN2 | |
| SCHEMBL3170137 | 0.83 | KDM4E (0.57) | MAPTALDH1A1PTGS2KMT2ASMN1; SMN2 | |
| SCHEMBL14395720 | 0.82 | CYP1A2 (0.58) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL13033693 | 0.82 | STAT3 (0.51) | MAPTGAAALDH1A1KMT2ASMN1; SMN2 | |
| SCHEMBL7305309 | 0.82 | MAPT (0.50) | MAPTGAAALDH1A1PTGS2KMT2A | |
| SCHEMBL7305302 | 0.82 | MAPT (0.50) | MAPTGAAALDH1A1PTGS2KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0507650-B1 | Piperidine derivatives, their preparation and their therapeutic application | SYNTHELABO (FR) | 1996-05-22 | — | — | EP | disclosed |
| US-5280030-A | Containing 1-benz(oxazole, thiazole or imidazole)-4-imidazole piperidine compound | SYNTHELABO (FR) | 1994-01-18 | — | — | US | disclosed |
| EP-0507650-A1 | Piperidine derivatives, their preparation and their therapeutic application | SYNTHELABO (FR) | 1992-10-07 | — | — | EP | disclosed |