Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 2/20 | 0.43 |
| ▸ | POLB | P06746 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.42 |
| ▸ | LMNA | P02545 | 3/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.40 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305589 | 0.72 | SMN1; SMN2 (0.44) | TSHRPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL3279364 | 0.69 | TSHR (0.54) | TSHRPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL13404413 | 0.69 | SMN1; SMN2 (0.55) | TSHRPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5307467 | 0.68 | POLB (0.73) | POLBSMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL6422603 | 0.68 | ALDH1A1 (0.73) | TSHRSMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL7312862 | 0.68 | POLB (0.53) | TSHRPOLBSMN1; SMN2LMNAALDH1A1 | |
| SCHEMBL5915275 | 0.67 | POLB (0.71) | POLBSMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL10867673 | 0.66 | ACP1 (0.31) | — | |
| SCHEMBL7309460 | 0.66 | KDM4E (0.59) | TSHRSMN1; SMN2LMNAALDH1A1KMT2A | |
| SCHEMBL16733792 | 0.66 | OPRM1 (0.50) | TSHRPOLBSMN1; SMN2LMNAALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | claimed |
| US-5773456-A | EMPHYSEMA, RHEUMATOID ARTHRITIS AND PANCREATITIS | SANOFI (FR) | 1998-06-30 | — | — | US | disclosed |
| US-5578623-A | DRUGS FOR TREATMENT OF ARTHRITIS, PANCREATITIS, CYSTIC FIBROSIS, BRONCHITIS, RESPIRATORY DISORDERS | STERLING WINTHROP INC. (US) | 1996-11-26 | — | — | US | disclosed |
| US-5464852-A | Used in treatment of degenerative diseases | STERLING WINTHROP INC. (US) | 1995-11-07 | — | — | US | disclosed |
| US-5380737-A | Enzyme inhibitors | STERLING WINTHROP INC. (US) | 1995-01-10 | — | — | US | disclosed |
| EP-0542371-A1 | Saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |