Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | ADRB3 | P13945 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | NPY1R | P25929 | 1/20 | 0.40 |
| ▸ | NPY2R | P49146 | 1/20 | 0.40 |
| ▸ | ADRB2 | P07550 | 2/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7304909 | 0.98 | MAPT (0.43) | MAPTKMT2AADRB3LMNANPY1R | |
| SCHEMBL7304907 | 0.93 | KMT2A (0.44) | MAPTKMT2AADRB3LMNANPY1R | |
| SCHEMBL7296572 | 0.91 | ADRB1 (0.49) | KMT2AADRB3LMNAADRB2 | |
| SCHEMBL7302226 | 0.88 | LMNA (0.48) | KMT2AADRB3LMNANPY1RNPY2R | |
| SCHEMBL7299736 | 0.88 | KMT2A (0.45) | MAPTKMT2AADRB3LMNANPY1R | |
| SCHEMBL7303245 | 0.87 | ADRB2 (0.48) | MAPTKMT2AADRB3LMNANPY1R | |
| SCHEMBL7296328 | 0.87 | LMNA (0.47) | KMT2ALMNANPY1RNPY2RADRB2 | |
| SCHEMBL9686910 | 0.85 | ADRB2 (0.47) | MAPTKMT2AADRB3LMNANPY1R | |
| SCHEMBL7297332 | 0.85 | LMNA (0.47) | MAPTKMT2AADRB3LMNANPY1R | |
| SCHEMBL7296778 | 0.85 | ATM (0.45) | MAPTKMT2AADRB3LMNANPY1R |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |