Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 2/20 | 0.52 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.52 |
| ▸ | KDM1A | O60341 | 1/20 | 0.43 |
| ▸ | MAOB | P27338 | 1/20 | 0.43 |
| ▸ | EPHX2 | P34913 | 1/20 | 0.41 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.41 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | ACE | P12821 | 2/20 | 0.40 |
| ▸ | YAP1 | P46937 | 1/20 | 0.40 |
| ▸ | CTSS | P25774 | 2/20 | 0.39 |
| ▸ | KCNA3 | P22001 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.39 |
| ▸ | CTSB | P07858 | 1/20 | 0.39 |
| ▸ | CTSK | P43235 | 1/20 | 0.39 |
| ▸ | SCN9A | Q15858 | 2/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7305721 | 1.00 | KMT2A (0.52) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL9326326 | 0.90 | KMT2A (0.48) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL7305948 | 0.90 | KMT2A (0.48) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL7307138 | 0.82 | KMT2A (0.51) | KMT2AL3MBTL1MAPK1YAP1KCNA3 | |
| SCHEMBL7381400 | 0.82 | KMT2A (0.51) | KMT2AL3MBTL1MAPK1YAP1KCNA3 | |
| SCHEMBL7304024 | 0.82 | KMT2A (0.52) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL7304028 | 0.82 | KMT2A (0.52) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL7374289 | 0.77 | L3MBTL1 (0.74) | KMT2AL3MBTL1KDM1AMAOBEPHX2 | |
| SCHEMBL7295795 | 0.77 | L3MBTL1 (0.48) | KMT2AL3MBTL1KDM1AMAOBMAPK1 | |
| SCHEMBL7305910 | 0.73 | KMT2A (0.55) | KMT2AL3MBTL1MAPK1KCNA3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5374731-A | Treatment of high blood pressure, congestive heart failure and viral disorders | HOECHST AKTIENGESELLSCHAFT (DE) | 1994-12-20 | — | — | US | disclosed |
| EP-0417698-A2 | Amino acid derivatives having renin-inhibiting activity, process for their preparation, agents containing them, and their use | HOECHST AKTIENGESELLSCHAFT (DE) | 1991-03-20 | — | — | EP | disclosed |