Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 3/20 | 0.39 |
| ▸ | MEN1 | O00255 | 3/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 9/20 | 0.36 |
| ▸ | GAA | P10253 | 2/20 | 0.35 |
| ▸ | POLB | P06746 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
| ▸ | GABRP | O00591 | 2/20 | 0.32 |
| ▸ | GABRD | O14764 | 2/20 | 0.32 |
| ▸ | GABRA1 | P14867 | 2/20 | 0.32 |
| ▸ | GABRB1 | P18505 | 2/20 | 0.32 |
| ▸ | GABRG2 | P18507 | 2/20 | 0.32 |
| ▸ | GABRB3 | P28472 | 2/20 | 0.32 |
| ▸ | GABRA5 | P31644 | 2/20 | 0.32 |
| ▸ | GABRA3 | P34903 | 2/20 | 0.32 |
| ▸ | GABRA2 | P47869 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7302490 | 0.80 | TSHR (0.59) | TSHRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL31078276 | 0.79 | TSHR (0.35) | TSHRALDH1A1MAPTNR1I2AHR | |
| SCHEMBL7352542 | 0.77 | TSHR (0.56) | TSHRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8552268 | 0.76 | TSHR (0.55) | TSHRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL2200208 | 0.75 | TSHR (0.54) | TSHRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8552869 | 0.73 | TSHR (0.52) | TSHRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL8553278 | 0.73 | TSHR (0.52) | TSHRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL7303767 | 0.71 | TSHR (1.00) | TSHRMEN1KMT2AALDH1A1MAPT | |
| SCHEMBL18282951 | 0.71 | TSHR (0.46) | TSHRLMNAMEN1KMT2AALDH1A1 | |
| SCHEMBL18641787 | 0.70 | ADORA1 (0.45) | TSHRMEN1KMT2AALDH1A1TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0636626-A1 | Pyrazolopyrimidine Derivatives | LABORATOIRES GLAXO SA (FR) | 1995-02-01 | — | — | EP | disclosed |