Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.63 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.38 |
| ▸ | HPGD | P15428 | 3/20 | 0.38 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.38 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.38 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.36 |
| ▸ | HTT | P42858 | 3/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | CCR6 | P51684 | 1/20 | 0.36 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.36 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.36 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | MAPK1 | P28482 | 4/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.35 |
| ▸ | MEN1 | O00255 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL10351658 | 0.81 | TSHR (0.68) | TSHRALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL9779798 | 0.78 | TSHR (0.50) | TSHRALDH1A1HPGDSMN1; SMN2HTT | |
| SCHEMBL9557112 | 0.75 | TSHR (0.72) | TSHRALDH1A1TDP1MAPTNPC1 | |
| SCHEMBL15740126 | 0.75 | TSHR (0.55) | TSHRALDH1A1HPGDALOX15HSD17B10 | |
| SCHEMBL15720303 | 0.74 | TSHR (0.54) | TSHRALDH1A1HSD17B10HTTMAPT | |
| SCHEMBL11124409 | 0.73 | TSHR (0.60) | TSHRALDH1A1HPGDSMN1; SMN2MAPK1 | |
| SCHEMBL14557358 | 0.71 | TSHR (0.50) | TSHRALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL18110443 | 0.71 | TSHR (0.50) | TSHRALDH1A1HPGDHSD17B10SMN1; SMN2 | |
| SCHEMBL7307335 | 0.67 | ELANE (0.54) | TSHRALDH1A1HPGDSMN1; SMN2NPC1 | |
| SCHEMBL10844281 | 0.63 | TSHR (0.50) | TSHRALDH1A1HPGDSMN1; SMN2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5874432-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | SANOFI (FR) | 1999-02-23 | — | — | US | disclosed |
| EP-0471756-B1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | SANOFI SA (FR) | 1997-10-29 | — | — | EP | disclosed |
| US-5650422-A | TREATMENT OF EMPHYSEMA, ARTHRITIS OR PANCREATITIS | SANOFI (FR) | 1997-07-22 | — | — | US | disclosed |
| US-5596012-A | Saccharin derivatives useful as proteolytic enzyme inhibitors and compositions and method of use thereof | STERLING WINTHROP INC. (US) | 1997-01-21 | — | — | US | disclosed |
| US-5371074-A | Use of saccharin derivatives as proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1994-12-06 | — | — | US | disclosed |
| US-5236917-A | Respiratory system disorders, antiarthritic agents | STERLING WINTHROP INC. (US) | 1993-08-17 | — | — | US | disclosed |
| EP-0542372-A1 | 2-Substituted saccharin derivative proteolytic enzyme inhibitors | STERLING WINTHROP INC. (US) | 1993-05-19 | — | — | EP | disclosed |
| EP-0471756-A4 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | — | 1992-04-08 | — | — | EP | disclosed |
| EP-0471756-A1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF. | STERLING WINTHROP INC (US) | 1992-02-26 | — | — | EP | disclosed |
| WO-1990013549-A1 | SACCHARIN DERIVATIVES USEFUL AS PROTEOLYTIC ENZYME INHIBITORS AND PREPARATION THEREOF | STERLING WINTHROP INC. (US) | 1990-11-15 | — | — | WO | disclosed |
| EP-0056444-B1 | PHOTOGRAPHIC ELEMENTS CONTAINING BLOCKED PHOTOGRAPHIC REAGENTS AND PROCESSES EMPLOYING SAME | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1984-05-09 | — | — | EP | disclosed |
| US-4350752-A | Photographic elements and film units containing imidomethyl blocked photographic reagents | EASTMAN KODAK COMPANY (US) | 1982-09-21 | — | — | US | disclosed |
| EP-0056444-A2 | Photographic elements containing blocked photographic reagents and processes employing same | EASTMAN KODAK COMPANY (a New Jersey corporation) (US) | 1982-07-28 | — | — | EP | disclosed |
| US-4146396-A | TWO EQUIVALENT COUPLER | FUJI PHOTO FILM CO., LTD. (JP) | 1979-03-27 | — | — | US | disclosed |