Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MTNR1A | P48039 | 5/20 | 0.48 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.45 |
| ▸ | AGTR2 | P50052 | 1/20 | 0.43 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | ACE | P12821 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | HTR2C | P28335 | 1/20 | 0.40 |
| ▸ | HTR2B | P41595 | 1/20 | 0.40 |
| ▸ | NQO2 | P16083 | 3/20 | 0.40 |
| ▸ | MTNR1B | P49286 | 3/20 | 0.40 |
| ▸ | AKR1B10 | O60218 | 1/20 | 0.40 |
| ▸ | AKR1B1 | P15121 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8742789 | 1.00 | MTNR1A (0.48) | MTNR1ANOTUMAGTR2HSD17B10ALDH1A1 | |
| SCHEMBL8742926 | 0.89 | MTNR1A (0.47) | MTNR1ANOTUMHSD17B10ALDH1A1LMNA | |
| SCHEMBL8742853 | 0.89 | MTNR1A (0.47) | MTNR1ANOTUMHSD17B10ALDH1A1LMNA | |
| SCHEMBL7316234 | 0.89 | MTNR1A (0.47) | MTNR1ANOTUMHSD17B10ALDH1A1LMNA | |
| SCHEMBL7343587 | 0.86 | NOTUM (0.50) | MTNR1ANOTUMAGTR2HSD17B10ALDH1A1 | |
| SCHEMBL7343593 | 0.86 | NOTUM (0.50) | MTNR1ANOTUMAGTR2HSD17B10ALDH1A1 | |
| SCHEMBL7307135 | 0.85 | MTNR1A (0.46) | MTNR1ANOTUMAGTR2HSD17B10ALDH1A1 | |
| SCHEMBL8742995 | 0.83 | NOTUM (0.45) | MTNR1ANOTUMHSD17B10ALDH1A1LMNA | |
| SCHEMBL8742991 | 0.83 | NOTUM (0.45) | MTNR1ANOTUMHSD17B10ALDH1A1LMNA | |
| SCHEMBL8742962 | 0.83 | NOTUM (0.45) | MTNR1ANOTUMHSD17B10ALDH1A1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0699680-B1 | Oxazoloquinolinone derivatives, their preparation and their use in therapy | SANOFI SYNTHELABO (FR) | 2000-03-08 | — | — | EP | claimed |
| US-5641785-A | ANTIDEPRESSANTS, NERVOUS SYSTEM DISORDERS | SYNTHELABO (FR) | 1997-06-24 | — | — | US | claimed |
| US-5641785-A | ANTIDEPRESSANTS, NERVOUS SYSTEM DISORDERS | SYNTHELABO (FR) | 1997-06-24 | — | — | US | disclosed |