Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LTA4H | P09960 | 5/20 | 0.44 |
| ▸ | TSHR | P16473 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.36 |
| ▸ | CA4 | P22748 | 1/20 | 0.36 |
| ▸ | NR1H2 | P55055 | 1/20 | 0.35 |
| ▸ | BAX | Q07812 | 1/20 | 0.35 |
| ▸ | MAOA | P21397 | 1/20 | 0.35 |
| ▸ | MAPT | P10636 | 2/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.35 |
| ▸ | GLA | P06280 | 1/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.35 |
| ▸ | HTT | P42858 | 2/20 | 0.35 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.34 |
| ▸ | GRM5 | P41594 | 1/20 | 0.33 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.33 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | RAB9A | P51151 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1451346 | 0.84 | LTA4H (0.55) | LTA4HTSHRMAOBCA4NR1H2 | |
| SCHEMBL18274775 | 0.79 | LTA4H (0.50) | LTA4HTSHRMAOBCA4NR1H2 | |
| SCHEMBL6003349 | 0.78 | LTA4H (0.48) | LTA4HTSHRMAOBCA4NR1H2 | |
| SCHEMBL8305561 | 0.77 | GCK (0.37) | MAPTKDM4EKMT2AHTTSMN1; SMN2 | |
| SCHEMBL10337545 | 0.77 | LTA4H (0.46) | LTA4HTSHRMAOBNR1H2BAX | |
| SCHEMBL1765125 | 0.75 | LTA4H (0.44) | LTA4HTSHRMAOBNR1H2BAX | |
| SCHEMBL6845975 | 0.75 | MAOA (0.50) | LTA4HTSHRMAOBNR1H2BAX | |
| SCHEMBL8124573 | 0.73 | BRD4 (0.35) | LTA4HTSHRMAPTKDM4EKMT2A | |
| SCHEMBL455316 | 0.73 | — | — | |
| SCHEMBL2302914 | 0.72 | LTA4H (0.46) | LTA4HTSHRMAOBCA4NR1H2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0634396-B1 | Amino acid derivatives and their use as inhibitors of encephalinase | BIOPROJET SOC CIV (FR) | 1998-10-28 | — | — | EP | disclosed |
| EP-0634396-A1 | Amino acid derivatives and their use as inhibitors of encephalinase | SOCIETE CIVILE BIOPROJET (FR) | 1995-01-18 | — | — | EP | disclosed |