Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4C | Q9H3R0 | 10/20 | 0.53 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.50 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.42 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | HCAR3 | P49019 | 1/20 | 0.40 |
| ▸ | SSTR5 | P35346 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 1/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7297157 | 0.90 | ALDH1A1 (0.47) | KDM4CKDM4EALDH1A1LMNATSHR | |
| SCHEMBL7306471 | 0.81 | KDM4C (0.50) | KDM4CKDM4EALDH1A1LMNATSHR | |
| SCHEMBL11154799 | 0.78 | ALDH1A1 (0.82) | KDM4CKDM4EALDH1A1LMNATSHR | |
| Hydrochloric Acid SCHEMBL7308170 | 0.77 | HTR3A (0.59) | ALDH1A1TSHRHSD17B10 | |
| SCHEMBL15792324 | 0.76 | KDM4C (0.46) | KDM4CKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL19597086 | 0.75 | ADORA2A (0.65) | KDM4CKDM4EALDH1A1LMNAKMT2A | |
| SCHEMBL7300207 | 0.74 | KMT2A (0.45) | KDM4CKDM4EALDH1A1LMNATSHR | |
| SCHEMBL7297551 | 0.74 | RORC (0.40) | KDM4CKDM4EALDH1A1LMNATSHR | |
| SCHEMBL24247693 | 0.74 | KDM4C (0.57) | KDM4CKDM4EALDH1A1LMNATSHR | |
| SCHEMBL3017718 | 0.74 | TSHR (0.53) | KDM4CKDM4EALDH1A1TSHRPMP22 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560604-B1 | Cinnoline-3-carboxylic acid derivatives as 5-HT3 antagonists | MITSUBISHI CHEM CORP (JP) | 1997-01-29 | — | — | EP | disclosed |
| US-5556851-A | TREATMENT OF NAUSEA OR EMESIS FROM ANTICANCER DRUGS OR X-RAY TREATMENT | MITSUBISHI CHEMICAL CORPORATION (JP) | 1996-09-17 | — | — | US | disclosed |
| US-5391549-A | Antagonistifc activity against serotonin 5HT3 receptors | MITSUBISHI KASEI CORPORATION (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0560604-A1 | Cinnoline-3-carboxylic acid derivatives as 5-HT3 antagonists | Mitsubishi Chemical Corporation (JP) | 1993-09-15 | — | — | EP | disclosed |