SCHEMBL7306219

SCHEMBL7306219

O=C(O)CNCCCc1ccccc1[N+](=O)[O-]

nearest known ligand 0.56

Predicted protein targets (top 17)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 4/20 0.50
KMT2A Q03164 4/20 0.50
KDM4E B2RXH2 3/20 0.50
TSHR P16473 1/20 0.46
L3MBTL1 Q9Y468 1/20 0.46
HDAC1 Q13547 1/20 0.45
POLB P06746 2/20 0.45
CYP2C19 P33261 2/20 0.45
MEN1 O00255 3/20 0.44
LMNA P02545 1/20 0.44
HPGD P15428 1/20 0.44
ATM Q13315 1/20 0.44
NPC1 O15118 2/20 0.44
RAB9A P51151 2/20 0.44
SMN1; SMN2 Q16637 2/20 0.44
CYP3A4 P08684 1/20 0.44
CYP2D6 P10635 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6775069 0.83 ALDH1A1 (0.56) ALDH1A1KMT2AKDM4ETSHRL3MBTL1
SCHEMBL4657892 0.83 ALDH1A1 (0.53) ALDH1A1KMT2ATSHRL3MBTL1HDAC1
SCHEMBL1352270 0.83 ALDH1A1 (0.53) ALDH1A1KMT2ATSHRL3MBTL1HDAC1
SCHEMBL10907668 0.82 ALDH1A1 (0.53) ALDH1A1KMT2AKDM4ETSHRL3MBTL1
SCHEMBL6754130 0.81 ALDH1A1 (0.51) ALDH1A1KMT2ATSHRL3MBTL1HDAC1
SCHEMBL6754133 0.81 ALDH1A1 (0.51) ALDH1A1KMT2ATSHRL3MBTL1HDAC1
SCHEMBL4609127 0.80 MAPT (0.54) ALDH1A1KMT2ATSHRL3MBTL1HDAC1
SCHEMBL4610015 0.80 MAPT (0.54) ALDH1A1KMT2ATSHRL3MBTL1HDAC1
SCHEMBL6754408 0.80 MAPT (0.54) ALDH1A1KMT2ATSHRL3MBTL1HDAC1
SCHEMBL7315272 0.80 FBP1 (0.39) ALDH1A1KMT2AKDM4ETSHRL3MBTL1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-RE31617-E ANTICOAGULANTS; HYPOTENSIVE AND BRONCHODILATOR AGENTS BRISTOL-MYERS COMPANY (US) 1984-06-26 US disclosed
US-3983120-A HYPOTENSIVES, ANTICLOTTING BRISTOL-MYERS COMPANY (US) 1976-09-28 US disclosed
US-3932407-A BRONCHODILATORS, HYPOTENSIVE AGENTS, ANTICOAGULANTS BRISTOL-MYERS COMPANY (US) 1976-01-13 US disclosed