Predicted protein targets (top 4)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.34 |
| ▸ | FOXM1 | Q08050 | 2/20 | 0.33 |
| ▸ | NPC1 | O15118 | 1/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7294572 | 0.98 | NPC1 (0.36) | LIPGFOXM1NPC1HPGD | |
| SCHEMBL7334694 | 0.97 | LIPG (0.34) | LIPGFOXM1NPC1 | |
| SCHEMBL7306535 | 0.93 | LIPG (0.35) | LIPG | |
| SCHEMBL7295050 | 0.85 | FFAR4 (0.33) | FOXM1NPC1HPGD | |
| SCHEMBL7296549 | 0.84 | CTSL (0.39) | — | |
| SCHEMBL7323836 | 0.84 | NPC1 (0.35) | FOXM1NPC1HPGD | |
| SCHEMBL7296929 | 0.84 | HRH3 (0.40) | NPC1 | |
| SCHEMBL7337609 | 0.83 | HRH3 (0.39) | NPC1HPGD | |
| SCHEMBL3950555 | 0.82 | CTSL (0.41) | — | |
| SCHEMBL7304360 | 0.82 | FFAR4 (0.33) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5135932-A | 2-HYDROXYPROPYLAMINO-ALKYL-BENZIMIDAZOLY-5-YL DERIVATIVES AND THEIR USE IN THE TREATMENT OF HEART DISEASE | DR. KARL THOMAE GMBH (DE) | 1992-08-04 | — | — | US | disclosed |
| EP-0400519-A1 | 2-Hydroxy-n-propylamines, medicaments containing these compounds and method for preparing them | Dr. Karl Thomae GmbH (DE) | 1990-12-05 | — | — | EP | disclosed |