Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.65 |
| ▸ | MMP2 | P08253 | 11/20 | 0.65 |
| ▸ | MMP3 | P08254 | 10/20 | 0.65 |
| ▸ | PDE4A | P27815 | 4/20 | 0.65 |
| ▸ | PDE4B | Q07343 | 4/20 | 0.65 |
| ▸ | PDE4C | Q08493 | 4/20 | 0.65 |
| ▸ | PDE4D | Q08499 | 4/20 | 0.65 |
| ▸ | MMP13 | P45452 | 9/20 | 0.63 |
| ▸ | MMP9 | P14780 | 8/20 | 0.63 |
| ▸ | ADAM17 | P78536 | 4/20 | 0.60 |
| ▸ | CA1 | P00915 | 1/20 | 0.53 |
| ▸ | CA2 | P00918 | 1/20 | 0.53 |
| ▸ | CA9 | Q16790 | 1/20 | 0.53 |
| ▸ | MMP8 | P22894 | 2/20 | 0.49 |
| ▸ | MMP12 | P39900 | 2/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | MMP16 | P51512 | 1/20 | 0.49 |
| ▸ | MMP7 | P09237 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7301899 | 0.85 | MMP1 (0.49) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6934594 | 0.80 | MMP1 (0.73) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL9246091 | 0.79 | MMP1 (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL13350334 | 0.79 | MMP1 (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6823055 | 0.79 | MMP1 (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL8714771 | 0.77 | MMP13 (0.73) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6929323 | 0.77 | MMP13 (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6928607 | 0.77 | MMP1 (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6927179 | 0.75 | MMP1 (1.00) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL1847769 | 0.75 | MMP1 (1.00) | MMP1MMP2MMP3PDE4APDE4B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |