Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 13/20 | 0.49 |
| ▸ | MMP2 | P08253 | 9/20 | 0.49 |
| ▸ | MMP3 | P08254 | 8/20 | 0.49 |
| ▸ | PDE4A | P27815 | 2/20 | 0.49 |
| ▸ | PDE4B | Q07343 | 2/20 | 0.49 |
| ▸ | PDE4C | Q08493 | 2/20 | 0.49 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.49 |
| ▸ | MMP13 | P45452 | 9/20 | 0.49 |
| ▸ | MMP9 | P14780 | 9/20 | 0.49 |
| ▸ | ADAM17 | P78536 | 3/20 | 0.47 |
| ▸ | CA1 | P00915 | 1/20 | 0.42 |
| ▸ | CA2 | P00918 | 1/20 | 0.42 |
| ▸ | CA9 | Q16790 | 1/20 | 0.42 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.41 |
| ▸ | MMP8 | P22894 | 1/20 | 0.41 |
| ▸ | MMP12 | P39900 | 1/20 | 0.41 |
| ▸ | MMP14 | P50281 | 1/20 | 0.41 |
| ▸ | MMP16 | P51512 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7306444 | 0.85 | MMP1 (0.65) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7305749 | 0.80 | MMP13 (0.71) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7309436 | 0.75 | MMP1 (0.50) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL7311621 | 0.74 | ALDH1A1 (0.44) | ADAM17CA1CA2HSD17B10ALDH1A1 | |
| SCHEMBL7344510 | 0.72 | SLC1A3 (0.56) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL7344506 | 0.72 | SLC1A3 (0.56) | MMP1MMP2MMP3MMP13MMP9 | |
| SCHEMBL7212138 | 0.70 | MMP13 (0.54) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL30720709 | 0.69 | MMP13 (0.56) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL7207037 | 0.69 | MMP1 (0.55) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL14636309 | 0.68 | SLC1A3 (0.41) | MMP1MMP2MMP3MMP13MMP9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |