Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ESR1 | P03372 | 2/20 | 0.56 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.53 |
| ▸ | MAPT | P10636 | 6/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 5/20 | 0.46 |
| ▸ | TSHR | P16473 | 4/20 | 0.46 |
| ▸ | MEN1 | O00255 | 3/20 | 0.46 |
| ▸ | HPGD | P15428 | 2/20 | 0.46 |
| ▸ | USP2 | O75604 | 1/20 | 0.46 |
| ▸ | PKM | P14618 | 1/20 | 0.43 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.42 |
| ▸ | RAB9A | P51151 | 2/20 | 0.42 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | BLM | P54132 | 1/20 | 0.40 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.40 |
| ▸ | POLB | P06746 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7300207 | 0.86 | KMT2A (0.45) | ESR1KDM4CMAPTKMT2ATSHR | |
| SCHEMBL7306471 | 0.80 | KDM4C (0.50) | KDM4CMAPTKMT2ATSHRMEN1 | |
| SCHEMBL26581142 | 0.79 | MAPT (0.50) | ESR1KDM4CMAPTKMT2ATSHR | |
| Hydrochloric Acid SCHEMBL7297378 | 0.77 | HTR3A (0.55) | TSHRALDH1A1KDM4E | |
| SCHEMBL15792317 | 0.76 | ESR1 (0.58) | ESR1KDM4CKMT2ATSHRMEN1 | |
| SCHEMBL19597178 | 0.75 | ESR1 (0.61) | ESR1KDM4CKMT2AMEN1ALDH1A1 | |
| SCHEMBL25097642 | 0.72 | ALOX15 (0.43) | ESR1MAPTKMT2ATSHRMEN1 | |
| SCHEMBL31429465 | 0.72 | RAB9A (0.50) | ESR1KDM4CMAPTKMT2ATSHR | |
| SCHEMBL4029768 | 0.72 | ESR1 (1.00) | ESR1KDM4CMAPTKMT2ATSHR | |
| SCHEMBL3017718 | 0.72 | TSHR (0.53) | KDM4CMAPTKMT2ATSHRMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0560604-B1 | Cinnoline-3-carboxylic acid derivatives as 5-HT3 antagonists | MITSUBISHI CHEM CORP (JP) | 1997-01-29 | — | — | EP | disclosed |
| US-5391549-A | Antagonistifc activity against serotonin 5HT3 receptors | MITSUBISHI KASEI CORPORATION (JP) | 1995-02-21 | — | — | US | disclosed |
| EP-0560604-A1 | Cinnoline-3-carboxylic acid derivatives as 5-HT3 antagonists | Mitsubishi Chemical Corporation (JP) | 1993-09-15 | — | — | EP | disclosed |