Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | RAB9A | P51151 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 3/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729233 | 0.88 | MAPT (0.53) | MAPTNPSR1L3MBTL1MAPK1CYP2D6 | |
| SCHEMBL23376910 | 0.83 | MAPT (0.64) | MAPTNPSR1L3MBTL1MAPK1CYP2D6 | |
| SCHEMBL28794446 | 0.83 | MAPT (0.64) | MAPTNPSR1L3MBTL1MAPK1CYP2D6 | |
| SCHEMBL7306746 | 0.81 | MAPT (0.47) | MAPTNPSR1L3MBTL1MAPK1CYP2D6 | |
| SCHEMBL3358932 | 0.76 | ALDH1A1 (0.40) | MAPTNPSR1L3MBTL1ALDH1A1LMNA | |
| SCHEMBL18344279 | 0.73 | CYP2D6 (0.40) | MAPTNPSR1L3MBTL1MAPK1CYP2D6 | |
| SCHEMBL10726885 | 0.72 | MAPT (0.51) | MAPTNPSR1L3MBTL1MAPK1CYP2D6 | |
| SCHEMBL10589007 | 0.71 | NPSR1 (0.50) | MAPTNPSR1L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL11858146 | 0.71 | ALDH1A1 (0.44) | MAPTNPSR1L3MBTL1MAPK1ALDH1A1 | |
| SCHEMBL5204 | 0.70 | MAPK1 (0.42) | MAPK1ALDH1A1LMNAKMT2ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | claimed |
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0727425-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-08-21 | — | — | EP | disclosed |