Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.38 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.38 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.36 |
| ▸ | LMNA | P02545 | 2/20 | 0.36 |
| ▸ | HPGD | P15428 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.36 |
| ▸ | TSHR | P16473 | 4/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.36 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.36 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | MGAM | O43451 | 1/20 | 0.35 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | SI | P14410 | 1/20 | 0.35 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.35 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9729233 | 0.88 | MAPT (0.53) | MAPTNPSR1MAPK1L3MBTL1CYP2D6 | |
| SCHEMBL1418032 | 0.87 | NPSR1 (0.40) | MAPTNPSR1MAPK1L3MBTL1SIGMAR1 | |
| SCHEMBL6422237 | 0.85 | SIGMAR1 (0.40) | MAPTNPSR1MAPK1L3MBTL1SIGMAR1 | |
| Hydrochloric Acid SCHEMBL7957925 | 0.83 | SIGMAR1 (0.40) | MAPTNPSR1MAPK1L3MBTL1SIGMAR1 | |
| SCHEMBL23376910 | 0.83 | MAPT (0.64) | MAPTNPSR1MAPK1L3MBTL1CYP2D6 | |
| SCHEMBL28794446 | 0.83 | MAPT (0.64) | MAPTNPSR1MAPK1L3MBTL1CYP2D6 | |
| SCHEMBL2533889 | 0.82 | MGAM (0.36) | MAPTNPSR1MAPK1L3MBTL1SIGMAR1 | |
| SCHEMBL7306734 | 0.81 | MAPT (0.47) | MAPTNPSR1MAPK1L3MBTL1CYP2D6 | |
| Hydrochloric Acid SCHEMBL7421187 | 0.81 | SIGMAR1 (0.44) | MAPTNPSR1MAPK1L3MBTL1SIGMAR1 | |
| SCHEMBL1417909 | 0.79 | SIGMAR1 (0.39) | MAPTNPSR1MAPK1L3MBTL1SIGMAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | claimed |
| US-6455529-B1 | OXAZOLIDIN-2-ONE DERIVATIVES; ANTICOAGULANTS; ANTIMETASTASIS, ANTICARCINOGENIC, ANTIISCHEMIC, AND ANTIINFLAMMATORY AGENTS; OSTEOPOROSIS, ARTERIOSCLEROSIS | MERCK PATENT GESELLSCHAFT MIT BESCHRAENKTER HAFTUNG (DE) | 2002-09-24 | — | — | US | disclosed |
| US-5627197-A | Adhesion receptor antagonists | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-05-06 | — | — | US | disclosed |
| EP-0741133-A2 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-11-06 | — | — | EP | disclosed |
| CN-1134423-A | Adhesion receptor antagonists | MERCK PATENT GMBH (DE) | 1996-10-30 | — | — | CN | disclosed |
| EP-0727425-A1 | Adhesion receptor antagonists | MERCK PATENT GmbH (DE) | 1996-08-21 | — | — | EP | disclosed |