Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.34 |
| ▸ | CTSK | P43235 | 4/20 | 0.34 |
| ▸ | CTSS | P25774 | 3/20 | 0.34 |
| ▸ | CA12 | O43570 | 1/20 | 0.33 |
| ▸ | CA1 | P00915 | 1/20 | 0.33 |
| ▸ | CA7 | P43166 | 1/20 | 0.33 |
| ▸ | CA14 | Q9ULX7 | 1/20 | 0.33 |
| ▸ | ELANE | P08246 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.31 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.30 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.30 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.30 |
| ▸ | HTT | P42858 | 1/20 | 0.30 |
| ▸ | GAA | P10253 | 2/20 | 0.30 |
| ▸ | MEN1 | O00255 | 1/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7540300 | 0.96 | DGAT1 (0.39) | DGAT1LMNAHSD17B10CTSKCTSS | |
| SCHEMBL7427784 | 0.82 | DGAT1 (0.52) | DGAT1LMNAHSD17B10CTSKCTSS | |
| SCHEMBL4014794 | 0.80 | FFAR3 (0.35) | LMNAHSD17B10ELANEALDH1A1CYP1A2 | |
| SCHEMBL31462329 | 0.79 | DGAT1 (0.39) | DGAT1LMNAHSD17B10CTSKCTSS | |
| SCHEMBL27343845 | 0.79 | DGAT1 (0.39) | DGAT1LMNAHSD17B10CTSKCTSS | |
| SCHEMBL27877903 | 0.77 | LMNA (0.31) | LMNAHSD17B10 | |
| SCHEMBL375735 | 0.77 | FFAR3 (0.38) | LMNAHSD17B10ALDH1A1CYP1A2CYP2C19 | |
| SCHEMBL6372947 | 0.76 | DGAT1 (0.36) | DGAT1LMNAHSD17B10CTSKCTSS | |
| SCHEMBL24487968 | 0.76 | DGAT1 (0.43) | DGAT1LMNAHSD17B10CTSKCTSS | |
| SCHEMBL18467265 | 0.76 | ELANE (0.46) | DGAT1LMNAHSD17B10CTSKCTSS |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0684240-B1 | Hydroxamic acid derivatives with three ring substituents | HOFFMANN LA ROCHE (CH) | 2000-08-02 | — | — | EP | disclosed |
| US-6066662-A | USE IN CONTROL OR PREVENTION OF RHEUMATOID ARTHRITIS AND OSTEOARTHRITIS OR IN THE TREATMENT OF INVASIVE TUMOURS, ATHEROSCLEROSIS OR MULTIPLE SCLEROSIS | HOFFMANN-LA ROCHE INC. (US) | 2000-05-23 | — | — | US | disclosed |
| US-5731441-A | COLLAGENASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1998-03-24 | — | — | US | disclosed |
| US-5710167-A | Hydroxamic acid derivatives with tricyclic substitution for treating degenerative joint diseases | HOFFMANN-LA ROCHE INC. (US) | 1998-01-20 | — | — | US | disclosed |
| US-5698690-A | COLLAGENASE INHIBITORS; TREATMENT OF DEGENERATIVE JOINT DISEASES | HOFFMANN-LA ROCHE INC. (US) | 1997-12-16 | — | — | US | disclosed |
| US-5614625-A | COLLAGENASE INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1997-03-25 | — | — | US | disclosed |
| EP-0763013-A1 | HYDROXYLAMINE DERIVATIVES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1997-03-19 | — | — | EP | disclosed |
| WO-1995033709-A1 | HYDROXYLAMINE DERIVATIVES AND THEIR USE AS METALLOPROTEINASE INHIBITING AGENTS | F. HOFFMANN-LA ROCHE AG (CH) | 1995-12-14 | — | — | WO | disclosed |
| EP-0684240-A1 | Hydroxamic acid derivatives with tricyclic substitution | F. HOFFMANN-LA ROCHE AG (CH) | 1995-11-29 | — | — | EP | disclosed |