Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DGAT1 | O75907 | 1/20 | 0.52 |
| ▸ | CA12 | O43570 | 2/20 | 0.35 |
| ▸ | CA14 | Q9ULX7 | 2/20 | 0.35 |
| ▸ | CA1 | P00915 | 2/20 | 0.35 |
| ▸ | CA7 | P43166 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | CA2 | P00918 | 2/20 | 0.32 |
| ▸ | ELANE | P08246 | 1/20 | 0.31 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.31 |
| ▸ | CTSK | P43235 | 2/20 | 0.30 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.30 |
| ▸ | CTSS | P25774 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11592929 | 0.87 | DGAT1 (0.36) | DGAT1CA1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL7540300 | 0.82 | DGAT1 (0.39) | DGAT1CA12CA14CA1CA7 | |
| SCHEMBL7307178 | 0.82 | DGAT1 (0.39) | DGAT1CA12CA14CA1CA7 | |
| SCHEMBL28842397 | 0.77 | DGAT1 (0.48) | DGAT1CA12CA14CA1CA7 | |
| SCHEMBL24487968 | 0.74 | DGAT1 (0.43) | DGAT1CA12CA14CA1CA7 | |
| SCHEMBL28003851 | 0.74 | DGAT1 (0.43) | DGAT1CA12CA14CA1CA7 | |
| SCHEMBL18467265 | 0.74 | ELANE (0.46) | DGAT1CA12CA14CA1CA7 | |
| SCHEMBL9243513 | 0.73 | DGAT1 (0.41) | DGAT1CA1ALDH1A1LMNAHSD17B10 | |
| SCHEMBL16661305 | 0.72 | DGAT1 (0.58) | DGAT1CA12CA14CA1CA7 | |
| SCHEMBL2304603 | 0.72 | LMNA (0.41) | DGAT1CA1ALDH1A1LMNAHSD17B10 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1180099-A1 | NEW COMPOUNDS | AstraZeneca AB (SE) | 2002-02-20 | — | — | EP | disclosed |
| WO-2000066550-A1 | NEW COMPOUNDS | ASTRAZENECA AB (SE) | 2000-11-09 | — | — | WO | disclosed |