Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GLA | P06280 | 1/20 | 0.45 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.45 |
| ▸ | CTSC | P53634 | 11/20 | 0.44 |
| ▸ | GAA | P10253 | 2/20 | 0.44 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.44 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
| ▸ | RAB9A | P51151 | 2/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
| ▸ | LMNA | P02545 | 1/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.40 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.40 |
| ▸ | DPP4 | P27487 | 1/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 1/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 1/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 1/20 | 0.39 |
| ▸ | CTSL | P07711 | 1/20 | 0.38 |
| ▸ | CTSS | P25774 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27268932 | 0.80 | PKM (0.51) | GAASMN1; SMN2DPP4ALDH1A1 | |
| SCHEMBL7301262 | 0.79 | DPP4 (0.40) | GLABRCA1GAASMN1; SMN2DPP4 | |
| SCHEMBL14191010 | 0.77 | NPC1 (0.47) | GLABRCA1GAANPSR1CYP2C19 | |
| SCHEMBL1631750 | 0.75 | CTSC (0.59) | CTSCCYP2C19RAB9ASLC1A3SLC1A2 | |
| SCHEMBL2058609 | 0.75 | CTSC (0.59) | CTSCCYP2C19RAB9ASLC1A3SLC1A2 | |
| SCHEMBL19699149 | 0.75 | CTSC (0.59) | CTSCCYP2C19RAB9ASLC1A3SLC1A2 | |
| SCHEMBL6897729 | 0.74 | CYP2C19 (0.53) | CTSCCYP2C19RAB9ASLC1A3SLC1A2 | |
| SCHEMBL20543720 | 0.74 | CTSC (0.55) | CTSCCYP2C19RAB9ANPC1SMN1; SMN2 | |
| Hydrochloric Acid SCHEMBL28362983 | 0.74 | CTSC (0.58) | CTSCCYP2C19RAB9ASLC1A3SLC1A2 | |
| Hydrochloric Acid SCHEMBL2524346 | 0.74 | CTSC (0.58) | CTSCCYP2C19RAB9ASLC1A3SLC1A2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657453-B1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL MYERS SQUIBB CO (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5637698-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITOR | BRISTOL-MYERS SQUIBB CO. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5525723-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, NEUTRAL ENDOPEPTIDASE | BRISTOL-MYERS SQUIBB CO. (US) | 1996-06-11 | — | — | US | disclosed |
| EP-0657453-A1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |