Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DPP4 | P27487 | 2/20 | 0.40 |
| ▸ | DPP8 | Q6V1X1 | 1/20 | 0.40 |
| ▸ | DPP9 | Q86TI2 | 1/20 | 0.40 |
| ▸ | SLC1A3 | P43003 | 2/20 | 0.39 |
| ▸ | SLC1A2 | P43004 | 2/20 | 0.39 |
| ▸ | SLC1A1 | P43005 | 2/20 | 0.39 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.36 |
| ▸ | POLB | P06746 | 2/20 | 0.36 |
| ▸ | GLA | P06280 | 1/20 | 0.36 |
| ▸ | BRCA1 | P38398 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.35 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.35 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.35 |
| ▸ | HRH2 | P25021 | 1/20 | 0.35 |
| ▸ | HRH1 | P35367 | 1/20 | 0.35 |
| ▸ | ALPI | P09923 | 1/20 | 0.35 |
| ▸ | PKM | P14618 | 1/20 | 0.35 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27268932 | 0.84 | PKM (0.51) | DPP4ALDH1A1L3MBTL1POLBGAA | |
| SCHEMBL7307307 | 0.79 | GLA (0.45) | DPP4DPP8DPP9SLC1A3SLC1A2 | |
| SCHEMBL4515508 | 0.78 | L3MBTL1 (0.47) | ALDH1A1L3MBTL1POLBMAPTCYP1A2 | |
| SCHEMBL5692348 | 0.74 | SLC1A3 (0.47) | DPP4DPP8DPP9SLC1A3SLC1A2 | |
| SCHEMBL22775723 | 0.74 | SLC1A3 (0.47) | DPP4DPP8DPP9SLC1A3SLC1A2 | |
| SCHEMBL5222079 | 0.74 | SLC1A3 (0.47) | DPP4DPP8DPP9SLC1A3SLC1A2 | |
| Hydrochloric Acid SCHEMBL3995222 | 0.73 | ALDH1A1 (0.47) | DPP4DPP8DPP9SLC1A3SLC1A2 | |
| Hydrochloric Acid SCHEMBL6774341 | 0.73 | ALDH1A1 (0.47) | DPP4DPP8DPP9SLC1A3SLC1A2 | |
| SCHEMBL28683018 | 0.73 | CYP1A2 (0.48) | DPP4DPP8DPP9SLC1A3SLC1A2 | |
| SCHEMBL8882780 | 0.71 | ALDH1A1 (0.71) | ALDH1A1L3MBTL1POLBGLAGAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0657453-B1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL MYERS SQUIBB CO (US) | 1999-01-20 | — | — | EP | disclosed |
| US-5637698-A | ANGIOTENSIN CONVERTING ENZYME AND NEUTRAL ENDOPEPTIDASE INHIBITOR | BRISTOL-MYERS SQUIBB CO. (US) | 1997-06-10 | — | — | US | disclosed |
| US-5525723-A | INHIBITORS OF ANGIOTENSIN CONVERTING ENZYME, NEUTRAL ENDOPEPTIDASE | BRISTOL-MYERS SQUIBB CO. (US) | 1996-06-11 | — | — | US | disclosed |
| EP-0657453-A1 | Angiotensin converting enzyme (ace) inhibitors containing a fused multiple ring lactam | BRISTOL-MYERS SQUIBB COMPANY (US) | 1995-06-14 | — | — | EP | disclosed |