Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.47 |
| ▸ | RAB9A | P51151 | 3/20 | 0.47 |
| ▸ | HPGD | P15428 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 2/20 | 0.47 |
| ▸ | EPHX1 | P07099 | 4/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | LMNA | P02545 | 1/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | PLG | P00747 | 2/20 | 0.46 |
| ▸ | KLK1 | P06870 | 2/20 | 0.46 |
| ▸ | KLK6 | Q92876 | 2/20 | 0.46 |
| ▸ | POLB | P06746 | 1/20 | 0.46 |
| ▸ | KLKB1 | P03952 | 2/20 | 0.44 |
| ▸ | PLK1 | P53350 | 1/20 | 0.43 |
| ▸ | PPARG | P37231 | 1/20 | 0.43 |
| ▸ | NCOA2 | Q15596 | 1/20 | 0.43 |
| ▸ | NCOA1 | Q15788 | 1/20 | 0.43 |
| ▸ | NCOA3 | Q9Y6Q9 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16193023 | 0.83 | MAPT (0.54) | RAB9AALDH1A1LMNAKLKB1 | |
| SCHEMBL111906 | 0.81 | PLG (0.53) | PLGKLK1KLK6KLKB1 | |
| SCHEMBL28109108 | 0.80 | ALDH1A1 (0.65) | RAB9ANPC1ALDH1A1LMNA | |
| Hydrochloric Acid SCHEMBL7444704 | 0.80 | PLG (0.54) | PLGKLK1KLK6KLKB1 | |
| SCHEMBL7311970 | 0.79 | PLG (0.48) | PLGKLK1KLK6KLKB1 | |
| SCHEMBL27602582 | 0.78 | IDO1 (0.60) | SMN1; SMN2ALDH1A1 | |
| SCHEMBL23728134 | 0.77 | EPHX1 (0.71) | SMN1; SMN2RAB9ANPC1EPHX1ALDH1A1 | |
| SCHEMBL6833494 | 0.77 | ALDH1A1 (0.56) | SMN1; SMN2HPGDALDH1A1PLGKLKB1 | |
| SCHEMBL27517715 | 0.76 | ALDH1A1 (0.54) | SMN1; SMN2HPGDALDH1A1PLGKLKB1 | |
| SCHEMBL27323392 | 0.76 | KLKB1 (0.50) | RAB9ANPC1PLGKLK1KLK6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1050534-B1 | 2,3-methano-amino acid derivatives, process for their preparation and pharmaceutical compositions containing them | SERVIER LAB (FR) | 2001-12-05 | — | — | EP | disclosed |
| US-6288077-B1 | 2-AZABICYCLO(3.1.0)HEXANE-1,2-DICARBOXYLIC AMIDE OR 2-AZABICYCLO(4.1.0)HEPTANE-1,2-DICARBOXYLIC AMIDE DERIVATIVE; TRYPSIN-LIKE SERINE PROTEASE INHIBITOR; ANTICOAGULANTS | ADIR ET COMPAGNIE (FR) | 2001-09-11 | — | — | US | disclosed |
| EP-1050534-A1 | 2,3-methano-amino acid derivatives, process for their preparation and pharmaceutical compositions containing them | ADIR ET COMPAGNIE (FR) | 2000-11-08 | — | — | EP | disclosed |