SCHEMBL7307515

CC(C)C[C@@H](C=O)NC(=O)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)[C@H](CCCCNC(=O)OCc1ccccc1)NC(=O)OC(C)(C)C)C(C)C

nearest known ligand 0.54

Predicted protein targets (top 8)

	gene	UniProt	supporting neighbours	confidence
▸	CMA1	P23946	13/20	0.54

▸	ITGB3	P05106	1/20	0.54

▸	ITGA2B	P08514	1/20	0.54

▸	MALT1	Q9UDY8	1/20	0.52

▸	KLK7	P49862	1/20	0.47

▸	KLK5	Q9Y337	1/20	0.47

▸	F2	P00734	1/20	0.46

▸	PRSS1	P07477	1/20	0.46

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL7321341	0.92	CMA1 (0.56)	CMA1ITGB3ITGA2BMALT1KLK7
SCHEMBL7320990	0.91	CMA1 (0.55)	CMA1ITGB3ITGA2BMALT1KLK7
SCHEMBL7309936	0.89	ITGB3 (0.59)	CMA1ITGB3ITGA2BMALT1KLK7
SCHEMBL7320222	0.88	CMA1 (0.56)	CMA1ITGB3ITGA2BMALT1KLK7
SCHEMBL7312175	0.88	ITGB3 (0.58)	CMA1ITGB3ITGA2BMALT1KLK7
SCHEMBL7322601	0.87	ITGB3 (0.57)	CMA1ITGB3ITGA2BMALT1KLK7
SCHEMBL7314317	0.87	ITGB3 (0.59)	CMA1ITGB3ITGA2BMALT1KLK7
SCHEMBL7324440	0.87	MALT1 (0.59)	CMA1ITGB3ITGA2BMALT1
SCHEMBL7317534	0.86	ITGB3 (0.55)	CMA1ITGB3ITGA2BMALT1KLK7
SCHEMBL7315995	0.85	ITGB3 (0.62)	CMA1ITGB3ITGA2BKLK7KLK5

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
US-4691007-A	HUMAN LEUKOCYTE ELASTASE INHIBITORS	ICI AMERICAS INC. (US)	1987-09-01	—	—	US	disclosed
US-4596789-A	Pharmaceuticals	ICI AMERICAS INC. (US)	1986-06-24	—	—	US	disclosed
EP-0124317-A2	Proline derivatives	ICI AMERICAS INC. (US)	1984-11-07	—	—	EP	disclosed