Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SIGMAR1 | Q99720 | 4/20 | 0.43 |
| ▸ | MAP3K11 | Q16584 | 1/20 | 0.39 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | FLT3 | P36888 | 3/20 | 0.35 |
| ▸ | KIT | P10721 | 2/20 | 0.35 |
| ▸ | PDE5A | O76074 | 1/20 | 0.35 |
| ▸ | HTR2B | P41595 | 1/20 | 0.35 |
| ▸ | CASP7 | P55210 | 1/20 | 0.34 |
| ▸ | CASP6 | P55212 | 1/20 | 0.34 |
| ▸ | SRC | P12931 | 2/20 | 0.34 |
| ▸ | KDR | P35968 | 2/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 2/20 | 0.34 |
| ▸ | MTOR | P42345 | 2/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.34 |
| ▸ | ABL1 | P00519 | 1/20 | 0.34 |
| ▸ | EGFR | P00533 | 1/20 | 0.34 |
| ▸ | HCK | P08631 | 1/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307551 | 0.86 | SRC (0.34) | HDAC1HDAC8HDAC6PDE5ASRC | |
| SCHEMBL7321184 | 0.83 | PIK3CD (0.40) | SRCKDRPIK3CAMTORPIK3CD | |
| SCHEMBL7317680 | 0.78 | SRC (0.38) | PDE5ASRCKDRPIK3CAMTOR | |
| SCHEMBL8987482 | 0.74 | PDE5A (0.37) | HDAC1PDE5ASRCKDRPIK3CA | |
| SCHEMBL7312223 | 0.74 | TLR9 (0.39) | PDE5ASRCKDRPIK3CAMTOR | |
| SCHEMBL5595224 | 0.71 | SIGMAR1 (0.41) | SIGMAR1MAP3K11HDAC1HDAC8HDAC6 | |
| SCHEMBL9081191 | 0.68 | PDE4A (0.36) | SRCKDRPIK3CAMTORPIK3CD | |
| SCHEMBL3398936 | 0.68 | SIGMAR1 (0.48) | SIGMAR1HTR2B | |
| SCHEMBL7313010 | 0.68 | EGFR (0.36) | PDE5ASRCKDRPIK3CAMTOR | |
| SCHEMBL7312127 | 0.68 | PDE5A (0.42) | PDE5ASRCKDRPIK3CAMTOR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |