Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.36 |
| ▸ | BTK | Q06187 | 2/20 | 0.36 |
| ▸ | PDE5A | O76074 | 1/20 | 0.36 |
| ▸ | PDE4A | P27815 | 3/20 | 0.35 |
| ▸ | PDE4B | Q07343 | 3/20 | 0.35 |
| ▸ | PDE4C | Q08493 | 3/20 | 0.35 |
| ▸ | PDE4D | Q08499 | 3/20 | 0.35 |
| ▸ | SRC | P12931 | 10/20 | 0.34 |
| ▸ | ABL1 | P00519 | 9/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 7/20 | 0.34 |
| ▸ | HCK | P08631 | 7/20 | 0.34 |
| ▸ | KDR | P35968 | 7/20 | 0.34 |
| ▸ | PIK3CA | P42336 | 7/20 | 0.34 |
| ▸ | PIK3CB | P42338 | 7/20 | 0.34 |
| ▸ | MTOR | P42345 | 7/20 | 0.34 |
| ▸ | PIK3CG | P48736 | 7/20 | 0.34 |
| ▸ | EPHB4 | P54760 | 7/20 | 0.34 |
| ▸ | PRKDC | P78527 | 7/20 | 0.34 |
| ▸ | PI4KB | Q9UBF8 | 7/20 | 0.34 |
| ▸ | MERTK | Q12866 | 2/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7312127 | 0.93 | PDE5A (0.42) | EGFRBTKPDE5APDE4APDE4B | |
| SCHEMBL7320063 | 0.90 | EGFR (0.39) | EGFRBTKPDE5APDE4APDE4B | |
| SCHEMBL7322196 | 0.80 | SRC (0.40) | EGFRBTKPDE5ASRCABL1 | |
| SCHEMBL8987482 | 0.72 | PDE5A (0.37) | EGFRPDE5APDE4APDE4BPDE4C | |
| SCHEMBL7317680 | 0.72 | SRC (0.38) | EGFRPDE5APDE4APDE4BPDE4C | |
| SCHEMBL7312223 | 0.70 | TLR9 (0.39) | EGFRPDE5APDE4APDE4BPDE4C | |
| SCHEMBL7316542 | 0.69 | EGFR (0.37) | EGFRBTKSRCABL1PIK3CD | |
| SCHEMBL7307567 | 0.68 | SIGMAR1 (0.43) | EGFRPDE5ASRCABL1PIK3CD | |
| SCHEMBL6199245 | 0.68 | PDE5A (0.59) | PDE5AKDM4EALDH1A1HSD17B10 | |
| SCHEMBL7321184 | 0.68 | PIK3CD (0.40) | EGFRPDE4APDE4BPDE4CPDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5541187-A | HYPOTENSIVE AGENTS | STERLING WINTHROP INC. (US) | 1996-07-30 | — | — | US | disclosed |
| US-5294612-A | Hypotensive agents and cardiovascular disorders | STERLING WINTHROP INC. (US) | 1994-03-15 | — | — | US | disclosed |