Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA2 | P00918 | 2/20 | 0.53 |
| ▸ | CTSD | P07339 | 6/20 | 0.42 |
| ▸ | HSPA5 | P11021 | 1/20 | 0.41 |
| ▸ | HSPA9 | P38646 | 1/20 | 0.41 |
| ▸ | BACE1 | P56817 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7307580 | 1.00 | CA2 (0.53) | CA2CTSDHSPA5HSPA9BACE1 | |
| SCHEMBL7340428 | 0.85 | CA2 (0.52) | CA2CTSDHSPA5HSPA9BACE1 | |
| SCHEMBL7340432 | 0.85 | CA2 (0.52) | CA2CTSDHSPA5HSPA9BACE1 | |
| SCHEMBL6452553 | 0.84 | CA2 (0.62) | CA2CTSDBACE1 | |
| SCHEMBL7342550 | 0.82 | CA2 (0.59) | CA2CTSDBACE1 | |
| SCHEMBL7342544 | 0.82 | CA2 (0.59) | CA2CTSDBACE1 | |
| SCHEMBL7344438 | 0.80 | CA2 (0.52) | CA2CTSDBACE1 | |
| SCHEMBL7344442 | 0.80 | CA2 (0.52) | CA2CTSDBACE1 | |
| SCHEMBL7333725 | 0.80 | CA2 (0.52) | CA2CTSDBACE1 | |
| SCHEMBL7307928 | 0.80 | CA2 (0.52) | CA2CTSDBACE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0486948-B1 | Retroviral protease inhibiting compounds | ABBOTT LAB (US) | 2000-10-04 | — | — | EP | disclosed |
| EP-0997459-A1 | Intermediates for preparing retroviral protease inhibiting compounds | Abbott Laboratories (US) | 2000-05-03 | — | — | EP | disclosed |
| US-5648497-A | Retroviral protease inhibiting compounds | ABBOTT LABORAOTRIES (US) | 1997-07-15 | — | — | US | disclosed |
| US-5597926-A | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1997-01-28 | — | — | US | disclosed |
| US-5554783-A | (2R, 3R, 4S, 5S)-3-ACETOXY-2,5-BIS/BENZYLOXYCARBONYLAMINO/ -4-BROMO-1,5-DIPHENYLHEXANE | ABBOTT LABORATORIES (US) | 1996-09-10 | — | — | US | disclosed |
| US-5541334-A | TREATING HIV | ABBOTT LABORATORIES (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0486948-A2 | Retroviral protease inhibiting compounds | ABBOTT LABORATORIES (US) | 1992-05-27 | — | — | EP | disclosed |