Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CA1 | P00915 | 2/20 | 0.46 |
| ▸ | CA2 | P00918 | 2/20 | 0.46 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.44 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.42 |
| ▸ | GCGR | P47871 | 10/20 | 0.42 |
| ▸ | ADCY6 | O43306 | 4/20 | 0.41 |
| ▸ | ADCY3 | O60266 | 4/20 | 0.41 |
| ▸ | ADCY9 | O60503 | 4/20 | 0.41 |
| ▸ | ADCY5 | O95622 | 4/20 | 0.41 |
| ▸ | ADCY8 | P40145 | 4/20 | 0.41 |
| ▸ | ADCY7 | P51828 | 4/20 | 0.41 |
| ▸ | ADCY2 | Q08462 | 4/20 | 0.41 |
| ▸ | ADCY1 | Q08828 | 4/20 | 0.41 |
| ▸ | ADCY4 | Q8NFM4 | 4/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.40 |
| ▸ | CTSG | P08311 | 1/20 | 0.40 |
| ▸ | CTRB1 | P17538 | 1/20 | 0.40 |
| ▸ | CMA1 | P23946 | 1/20 | 0.40 |
| ▸ | CD274 | Q9NZQ7 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9339491 | 0.88 | HDAC1 (0.51) | CA1CA2GCGRADCY6ADCY3 | |
| SCHEMBL8382918 | 0.87 | ATM (0.48) | CA1CA2DGAT1PRSS1 | |
| SCHEMBL9336123 | 0.84 | ACHE (0.49) | GCGRADCY6ADCY3ADCY9ADCY5 | |
| SCHEMBL7302006 | 0.83 | SYK (0.46) | PRSS1CTSGCTRB1CMA1 | |
| SCHEMBL2651542 | 0.82 | CD274 (0.57) | CA1CA2MAPK1GCGRADCY6 | |
| SCHEMBL9335835 | 0.81 | BRD4 (0.45) | — | |
| SCHEMBL9865225 | 0.80 | HDAC1 (0.47) | PRSS1CD274 | |
| SCHEMBL617014 | 0.79 | MAPT (0.52) | CA1CA2 | |
| SCHEMBL7305490 | 0.79 | NR1H4 (0.45) | CA2 | |
| SCHEMBL16808225 | 0.79 | PPARA (0.46) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0445796-B1 | Derivatives of acetic acid containing peptide bonds | HOFFMANN LA ROCHE (CH) | 1998-06-17 | — | — | EP | disclosed |
| US-5430024-A | Peptides bearing N-terminal amidino moieties and their use as inhibitors of platelet aggregation | HOFFMANN-LA ROCHE INC. (US) | 1995-07-04 | — | — | US | disclosed |
| US-5273982-A | An amidinoaryleneamidoalkylpiperazinyleneacetic acid | HOFFMANN-LA ROCHE INC. (US) | 1993-12-28 | — | — | US | disclosed |
| EP-0445796-A2 | Derivatives of acetic acid | F. HOFFMANN-LA ROCHE AG (CH) | 1991-09-11 | — | — | EP | disclosed |