Known targets — ChEMBL curated mechanism
ACHEBDKRB2CHRM1CHRM2CHRM3CHRNA1CHRNB1CHRNDCHRNECHRNGGUCY1A1GUCY1A2GUCY1B1GUCY1B2NAMPTPTAFRSLC10A2SLC6A2SLC6A3TACR1dacAdacBdacCftsImrcAmrcBmrdA
The experimentally established mechanism targets of Hydrochloric Acid. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ACHE known ✓ | P22303 | 3/20 | 0.50 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.56 |
| ▸ | RAB9A | P51151 | 1/20 | 0.56 |
| ▸ | LMNA | P02545 | 4/20 | 0.55 |
| ▸ | CHKA | P35790 | 6/20 | 0.50 |
| ▸ | HTT | P42858 | 2/20 | 0.50 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.50 |
| ▸ | CHRNA7 | P36544 | 2/20 | 0.46 |
| ▸ | CHRNA10 | Q9GZZ6 | 2/20 | 0.46 |
| ▸ | CHRNA9 | Q9UGM1 | 2/20 | 0.46 |
| ▸ | BCHE | P06276 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.42 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5307716 | 0.98 | ALDH1A1 (0.53) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Bromide SCHEMBL26091565 | 0.86 | CHRNA7 (0.58) | LMNACHKAACHECHRNA7CHRNA10 | |
| Hydrochloric Acid SCHEMBL19468916 | 0.84 | ALDH1A1 (0.51) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Bromide SCHEMBL26090335 | 0.83 | ACHE (0.59) | CHKAACHECHRNA7CHRNA10CHRNA9 | |
| SCHEMBL4402996 | 0.82 | CHRNA7 (0.66) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Hydrochloric Acid SCHEMBL10670016 | 0.82 | ALDH1A1 (0.50) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| SCHEMBL15836459 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| SCHEMBL28927098 | 0.81 | ACHE (0.51) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Hydrochloric Acid SCHEMBL26627009 | 0.81 | ALDH1A1 (0.49) | ALDH1A1KDM4ERAB9ALMNACHKA | |
| Bromide SCHEMBL23858158 | 0.80 | CHKA (0.49) | ALDH1A1KDM4ERAB9ALMNACHKA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5290796-A | Central nervous system disorders, psychosis | STERLING WINTHROP INC. (US) | 1994-03-01 | — | — | US | disclosed |
| US-5290789-A | Antipsychotically effective compounds | STERLING WINTROP INC. (US) | 1994-03-01 | — | — | US | disclosed |
| US-5286733-A | Treating psychoses | STERLING WINTHROP INC. (US) | 1994-02-15 | — | — | US | disclosed |
| US-5240935-A | Central nervous system disorders | STERLING WINTHROP INC. (US) | 1993-08-31 | — | — | US | disclosed |