Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MMP1 | P03956 | 9/20 | 0.46 |
| ▸ | MMP2 | P08253 | 5/20 | 0.44 |
| ▸ | MMP3 | P08254 | 5/20 | 0.44 |
| ▸ | PDE4A | P27815 | 1/20 | 0.44 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.44 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.44 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.44 |
| ▸ | HDAC1 | Q13547 | 4/20 | 0.43 |
| ▸ | HDAC8 | Q9BY41 | 4/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.43 |
| ▸ | HDAC4 | P56524 | 2/20 | 0.43 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.43 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.43 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.43 |
| ▸ | HDAC11 | Q96DB2 | 2/20 | 0.43 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.43 |
| ▸ | HDAC9 | Q9UKV0 | 2/20 | 0.43 |
| ▸ | HDAC5 | Q9UQL6 | 2/20 | 0.43 |
| ▸ | MMP8 | P22894 | 4/20 | 0.43 |
| ▸ | MMP12 | P39900 | 4/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7870722 | 0.75 | MMP1 (0.56) | MMP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL6823261 | 0.72 | MMP1 (0.59) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6933354 | 0.72 | MMP1 (0.60) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL6932404 | 0.72 | MMP13 (0.60) | MMP1HDAC1HDAC8HDAC3HDAC2 | |
| SCHEMBL7298900 | 0.71 | MMP1 (0.48) | MMP1MMP2MMP3PDE4APDE4B | |
| SCHEMBL22912675 | 0.70 | CA1 (0.48) | MMP13CA1CA2 | |
| SCHEMBL6930501 | 0.69 | HDAC1 (0.60) | MMP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL6931713 | 0.69 | HDAC1 (0.60) | MMP1HDAC1HDAC8HDAC3HDAC4 | |
| SCHEMBL11986318 | 0.69 | CA1 (0.42) | CA1CA2 | |
| SCHEMBL11986321 | 0.69 | CA1 (0.42) | CA1CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0780386-B1 | Matrix metalloprotease inhibitors | HOFFMANN LA ROCHE (CH) | 2002-10-02 | — | — | EP | disclosed |
| US-5932595-A | ANTIARTHRITIC AGENT; MULTIPLE SCLEROSIS; OSTEOPOROSIS; RESPIRATORY SYSTEM DISORDERS; SKIN DISORDERS; ANTIULCER AGENT | SYNTEX (U.S.A.) INC. (US) | 1999-08-03 | — | — | US | disclosed |
| EP-0780386-A1 | Matrix metalloprotease inhibitors | F. HOFFMANN-LA ROCHE AG (CH) | 1997-06-25 | — | — | EP | disclosed |